Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

Rosa Bernardi, Pier Paolo Pandolfi

Research output: Contribution to journalArticle

Abstract

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.

Original languageEnglish
Pages (from-to)1006-1016
Number of pages11
JournalNature Reviews Molecular Cell Biology
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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