Structure, function and regulation of p63 and p73

M. Levrero, V. De Laurenzi, A. Costanzo, J. Gong, G. Melino, J. Y J Wang

Research output: Contribution to journalArticle

Abstract

The p53 tumor suppressor gene is one of the most frequently mutated genes in human cancers. p53 is a sequence-specific transcription factor and plays a critical role in activating the expression of genes involved in cell cycle arrest or apoptosis under conditions of genotoxic stress. For over two decades, p53 was thought to be the only gene of its kind in the vertebrate genomes. This strong conviction, which was widely accepted in the p53 field, has now been proven to be incorrect. Two genes, referred to as p63 and p73, have been found to encode proteins that share a significant amino-acid identity in the transactivation domain, the DNA binding domain, and the oligomerization domain with p53. In the short period since their cloning, a number of investigators have reported on the structure, the function and the regulation of p63 and p73. This review summarizes the current information on the p63 and the p73 genes, with a focus on the differences between the three members in this newly defined p53-gene family.

Original languageEnglish
Pages (from-to)1146-1153
Number of pages8
JournalCell Death and Differentiation
Volume6
Issue number12
Publication statusPublished - Dec 1999

Keywords

  • Apoptosis
  • c-Abl
  • p53
  • p73

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Levrero, M., De Laurenzi, V., Costanzo, A., Gong, J., Melino, G., & Wang, J. Y. J. (1999). Structure, function and regulation of p63 and p73. Cell Death and Differentiation, 6(12), 1146-1153.