Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family

Daniele De Sanctis, Alessandra Pesce, Marco Nardini, Martino Bolognesi, Alessio Bocedi, Paolo Ascenzi

Research output: Contribution to journalArticle

Abstract

Hemoglobin and related heme proteins, generally referred to as 'globins', reversibly bind gaseous diatomic ligands (O2, NO, and CO) to a penta-coordinate heme iron atom, the ligand filling the sixth coordination site. Over the last decade, several new globins have been reported to display a functionally-relevant hexa-coordinate heme iron atom, whose sixth coordination site is taken by an endogenous protein ligand. The reversible intramolecular hexa- to penta-coordination process at the heme-Fe atom modulates exogenous ligand binding properties of hexa-coordinate globins. Here, we review current knowledge on hexa-coordinate globins in terms of their structural and functional properties.

Original languageEnglish
Pages (from-to)643-651
Number of pages9
JournalIUBMB Life
Volume56
Issue number11-12
DOIs
Publication statusPublished - Nov 2004

Fingerprint

Globins
Hemoglobins
Heme
Ligands
Rubiaceae
Atoms
Iron
Hemeproteins
Carbon Monoxide
Proteins

Keywords

  • Cytoglobin
  • Hemoglobin
  • Hexacoordinate heme
  • Myoglobin
  • Neuroglobin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

De Sanctis, D., Pesce, A., Nardini, M., Bolognesi, M., Bocedi, A., & Ascenzi, P. (2004). Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family. IUBMB Life, 56(11-12), 643-651. https://doi.org/10.1080/15216540500059640

Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family. / De Sanctis, Daniele; Pesce, Alessandra; Nardini, Marco; Bolognesi, Martino; Bocedi, Alessio; Ascenzi, Paolo.

In: IUBMB Life, Vol. 56, No. 11-12, 11.2004, p. 643-651.

Research output: Contribution to journalArticle

De Sanctis, D, Pesce, A, Nardini, M, Bolognesi, M, Bocedi, A & Ascenzi, P 2004, 'Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family', IUBMB Life, vol. 56, no. 11-12, pp. 643-651. https://doi.org/10.1080/15216540500059640
De Sanctis D, Pesce A, Nardini M, Bolognesi M, Bocedi A, Ascenzi P. Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family. IUBMB Life. 2004 Nov;56(11-12):643-651. https://doi.org/10.1080/15216540500059640
De Sanctis, Daniele ; Pesce, Alessandra ; Nardini, Marco ; Bolognesi, Martino ; Bocedi, Alessio ; Ascenzi, Paolo. / Structure-function relationships in the growing hexa-coordinate hemoglobin sub-family. In: IUBMB Life. 2004 ; Vol. 56, No. 11-12. pp. 643-651.
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