Structure of fibrin networks

M. De Spirito, G. Arcovito, F. Andreasi Bassi, M. Rocco, E. Paganini, M. Greco, F. Ferri

Research output: Contribution to journalArticle

Abstract

The structure of fibrin gels grown at room temperature from fibrinogen solutions at sevei'al fibrinogen concentrations was investigated by means of elastic light scattering. By combining Classical Light Scattering (CLS) and Low-Angle Elastic Light Scattering (LAELS) an overall wavevector range of more than two decades was spanned, from 7.8 × 102 to 3.3 × 05 cm-1. The scattered intensity distribution I(q) of all the gels was characterized by three different regimes. For q = q1 ∼ 2.5 × 103 cm-1, I(q) exhibits a maximum which indicates the presence of a long-range order in the gel structure, with an average mesh size ζ1 = 2ζ/q1 ∼ 25μm. For q1 <q2(q2 ∼ 1-3 × 105 cm-1), the scattered intensity distribution decays with a power law characterized by the mass fractal exponent Dm = 1.20 ±0.05, which is typical of branched linear polymers. At larger wavevectors, for q > q2, there is a crossover to a scattering from surface fractals, where I(q) decays with a power law characterized by an exponent of ~ -4. The length scale ζ2 = 1/q2 ∼ 80 nm is an estimate of the average diameters of the gel fibers. All our results, including the kinetics of gel formation, can be described in terms of a simple model.

Original languageEnglish
Pages (from-to)2409-2417
Number of pages9
JournalIl Nuovo Cimento D
Volume20
Issue number12 SUPPL.
Publication statusPublished - 1999

Fingerprint

fibrin
gels
fibrinogen
light scattering
elastic scattering
mesh
fractals
crossovers
exponents
fibers
kinetics
decay
room temperature
estimates
scattering

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

De Spirito, M., Arcovito, G., Andreasi Bassi, F., Rocco, M., Paganini, E., Greco, M., & Ferri, F. (1999). Structure of fibrin networks. Il Nuovo Cimento D, 20(12 SUPPL.), 2409-2417.

Structure of fibrin networks. / De Spirito, M.; Arcovito, G.; Andreasi Bassi, F.; Rocco, M.; Paganini, E.; Greco, M.; Ferri, F.

In: Il Nuovo Cimento D, Vol. 20, No. 12 SUPPL., 1999, p. 2409-2417.

Research output: Contribution to journalArticle

De Spirito, M, Arcovito, G, Andreasi Bassi, F, Rocco, M, Paganini, E, Greco, M & Ferri, F 1999, 'Structure of fibrin networks', Il Nuovo Cimento D, vol. 20, no. 12 SUPPL., pp. 2409-2417.
De Spirito M, Arcovito G, Andreasi Bassi F, Rocco M, Paganini E, Greco M et al. Structure of fibrin networks. Il Nuovo Cimento D. 1999;20(12 SUPPL.):2409-2417.
De Spirito, M. ; Arcovito, G. ; Andreasi Bassi, F. ; Rocco, M. ; Paganini, E. ; Greco, M. ; Ferri, F. / Structure of fibrin networks. In: Il Nuovo Cimento D. 1999 ; Vol. 20, No. 12 SUPPL. pp. 2409-2417.
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