Structure of the human α1acid glycoprotein gene: Sequence homology with other human acute phase protein genes

Luciana Dente, Gennaro Ciliberto, Riccardo Cortese

Research output: Contribution to journalArticlepeer-review

Abstract

We have determined the sequence coding for human α1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α1AGP. We propose that α1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response

Original languageEnglish
Pages (from-to)3941-3952
Number of pages12
JournalNucleic Acids Research
Volume13
Issue number11
DOIs
Publication statusPublished - Jun 11 1985

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Genetics(clinical)
  • Genetics

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