Abstract
We have determined the sequence coding for human α1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α1AGP. We propose that α1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response
Original language | English |
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Pages (from-to) | 3941-3952 |
Number of pages | 12 |
Journal | Nucleic Acids Research |
Volume | 13 |
Issue number | 11 |
DOIs | |
Publication status | Published - Jun 11 1985 |
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Health, Toxicology and Mutagenesis
- Toxicology
- Genetics(clinical)
- Genetics