Abstract
We have determined the sequence coding for human α1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α1AGP. We propose that α1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response
| Original language | English |
|---|---|
| Pages (from-to) | 3941-3952 |
| Number of pages | 12 |
| Journal | Nucleic Acids Research |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jun 11 1985 |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Health, Toxicology and Mutagenesis
- Toxicology
- Genetics(clinical)
- Genetics
Cite this
Structure of the human α1acid glycoprotein gene : Sequence homology with other human acute phase protein genes. / Dente, Luciana; Ciliberto, Gennaro; Cortese, Riccardo.
In: Nucleic Acids Research, Vol. 13, No. 11, 11.06.1985, p. 3941-3952.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structure of the human α1acid glycoprotein gene
T2 - Sequence homology with other human acute phase protein genes
AU - Dente, Luciana
AU - Ciliberto, Gennaro
AU - Cortese, Riccardo
PY - 1985/6/11
Y1 - 1985/6/11
N2 - We have determined the sequence coding for human α1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α1AGP. We propose that α1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response
AB - We have determined the sequence coding for human α1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α1AGP. We propose that α1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response
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UR - http://www.scopus.com/inward/citedby.url?scp=0022423423&partnerID=8YFLogxK
U2 - 10.1093/nar/13.11.3941
DO - 10.1093/nar/13.11.3941
M3 - Article
C2 - 2409529
AN - SCOPUS:0022423423
VL - 13
SP - 3941
EP - 3952
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - 11
ER -