Structure of the human α1acid glycoprotein gene: Sequence homology with other human acute phase protein genes

Luciana Dente; Gennaro Ciliberto; Riccardo Cortese

doi:10.1093/nar/13.11.3941

Structure of the human α1acid glycoprotein gene: Sequence homology with other human acute phase protein genes

Luciana Dente, Gennaro Ciliberto, Riccardo Cortese

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

We have determined the sequence coding for human α₁-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α₁AGP. We propose that α₁AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α₁AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α₁antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response

Original language	English
Pages (from-to)	3941-3952
Number of pages	12
Journal	Nucleic Acids Research
Volume	13
Issue number	11
DOIs	https://doi.org/10.1093/nar/13.11.3941
Publication status	Published - Jun 11 1985

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Health, Toxicology and Mutagenesis
Toxicology
Genetics(clinical)
Genetics

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abstract = "We have determined the sequence coding for human α1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for α1AGP. We propose that α1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified α1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human α1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response",

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AU - Cortese, Riccardo

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