Structure of the Ly49 family of Natural Killer (NK) cell receptors and their interaction with MHC class I molecules

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Abstract

Natural killer (NK) cells are an essential component of the innate immunity toward tumors and virally infected cells. The function of NK cells is regulated by a precise balance between inhibitory and activating signals. These signals are mediated by NK cell receptors that bind either classical MHC class I molecules or their structural relatives such as MICA, ULBP, RAE-1, and H-60. Two separate families of NK cell receptors have been identified: the immunoglobulin-like family (KIR, LIR) and C-type lectin-like family (Ly49, NKG2D, and CD94/NKG2). Here we summarize the structure of Ly49 C-type lectin-like proteins hitherto solved (Ly49A, Ly49C and Ly49I) and their interaction with MHC class I molecules as determined by the co-crystal structure of Ly49A/H-2Dd and Ly49C/H-2Kb.

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalImmunologic Research
Volume30
Issue number1
Publication statusPublished - 2004

Keywords

  • Crystal structure
  • Immunoreceptors
  • Inhibitory receptors
  • Ly49
  • Ly49/MHC complex
  • MHC
  • Natural killer (NK)
  • NK Receptors

ASJC Scopus subject areas

  • Immunology

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