Apparent kinetic parameters Vmax and KM have been measured for the oxidative N-demethylation of twelve para-substituted N, N-dimethylanilines catalysed by rat liver microsomes. Vmax was enhanced by pretreatment of the rats with phénobarbital, whereas pretreatment with β-naphthoflavone gave no appreciable enhancement. In the case of phénobarbital pretreatment the kinetic parameters could be expressed in terms of lipophilic and electronic effect of the substituents. Kinetic parameters from control and β-naphthoflavone microsomes gave no statistically meaningful correlation.
|Number of pages||5|
|Journal||European Journal of Drug Metabolism and Pharmacokinetics|
|Publication status||Published - Oct 1984|
- Structure-reactivity relationships
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)