Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: A 24-week pilot study

S. Palomba, F. Giallauria, A. Falbo, T. Russo, R. Oppedisano, A. Tolino, A. Colao, C. Vigorito, F. Zullo, F. Orio

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

BACKGROUND: Lifestyle modifications are successfully employed to treat obese and overweight women with polycystic ovary syndrome (PCOS). The aims of the current pilot study were (i) to compare the efficacy on reproductive functions of a structured exercise training (SET) programme with a diet programme in obese PCOS patients and (ii) to study their clinical, hormonal and metabolic effects to elucidate potentially different mechanisms of action. METHODS: Forty obese PCOS patients with anovulatory infertility underwent a SET programme (SET group, n = 20) and a hypocaloric hyperproteic diet (diet group, n = 20). Clinical, hormonal and metabolic data were assessed at baseline, and at 12- and 24-week follow-ups. Primary endpoint was cumulative pregnancy rate. RESULTS: The two groups had similar demographic, anthropometric and biochemical parameters. After intervention, a significant improvement in menstrual cycles and fertility was noted in both groups, with no differences between groups. The frequency of menses and the ovulation rate were significantly (P <0.05) higher in the SET group than in diet group but the increased cumulative pregnancy rate was not significant. Body weight, body mass index, waist circumference, insulin resistance indexes and serum levels of sex hormone-binding globulin, androstenedione and dehydroepiandrosterone sulphate changed significantly (P <0.05) from baseline and were significantly different (P <0.05) between the two groups. CONCLUSIONS: Both SET and diet interventions improve fertility in obese PCOS patients with anovulatory infertility. We hypothesize that in both interventions an improvement in insulin sensitivity is the pivotal factor involved in the restoration of ovarian function but potentially acting through different mechanisms.

Original languageEnglish
Pages (from-to)642-650
Number of pages9
JournalHuman Reproduction
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Polycystic Ovary Syndrome
Infertility
Exercise
Diet
Education
Pregnancy Rate
Fertility
Insulin Resistance
Sex Hormone-Binding Globulin
Dehydroepiandrosterone Sulfate
Menstruation
Androstenedione
Waist Circumference
Menstrual Cycle
Ovulation
Life Style
Body Mass Index
Body Weight
Demography
Serum

Keywords

  • Diet
  • Exercise
  • Infertility
  • Obesity
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility : A 24-week pilot study. / Palomba, S.; Giallauria, F.; Falbo, A.; Russo, T.; Oppedisano, R.; Tolino, A.; Colao, A.; Vigorito, C.; Zullo, F.; Orio, F.

In: Human Reproduction, Vol. 23, No. 3, 03.2008, p. 642-650.

Research output: Contribution to journalArticle

Palomba, S, Giallauria, F, Falbo, A, Russo, T, Oppedisano, R, Tolino, A, Colao, A, Vigorito, C, Zullo, F & Orio, F 2008, 'Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: A 24-week pilot study', Human Reproduction, vol. 23, no. 3, pp. 642-650. https://doi.org/10.1093/humrep/dem391
Palomba, S. ; Giallauria, F. ; Falbo, A. ; Russo, T. ; Oppedisano, R. ; Tolino, A. ; Colao, A. ; Vigorito, C. ; Zullo, F. ; Orio, F. / Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility : A 24-week pilot study. In: Human Reproduction. 2008 ; Vol. 23, No. 3. pp. 642-650.
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AU - Giallauria, F.

AU - Falbo, A.

AU - Russo, T.

AU - Oppedisano, R.

AU - Tolino, A.

AU - Colao, A.

AU - Vigorito, C.

AU - Zullo, F.

AU - Orio, F.

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N2 - BACKGROUND: Lifestyle modifications are successfully employed to treat obese and overweight women with polycystic ovary syndrome (PCOS). The aims of the current pilot study were (i) to compare the efficacy on reproductive functions of a structured exercise training (SET) programme with a diet programme in obese PCOS patients and (ii) to study their clinical, hormonal and metabolic effects to elucidate potentially different mechanisms of action. METHODS: Forty obese PCOS patients with anovulatory infertility underwent a SET programme (SET group, n = 20) and a hypocaloric hyperproteic diet (diet group, n = 20). Clinical, hormonal and metabolic data were assessed at baseline, and at 12- and 24-week follow-ups. Primary endpoint was cumulative pregnancy rate. RESULTS: The two groups had similar demographic, anthropometric and biochemical parameters. After intervention, a significant improvement in menstrual cycles and fertility was noted in both groups, with no differences between groups. The frequency of menses and the ovulation rate were significantly (P <0.05) higher in the SET group than in diet group but the increased cumulative pregnancy rate was not significant. Body weight, body mass index, waist circumference, insulin resistance indexes and serum levels of sex hormone-binding globulin, androstenedione and dehydroepiandrosterone sulphate changed significantly (P <0.05) from baseline and were significantly different (P <0.05) between the two groups. CONCLUSIONS: Both SET and diet interventions improve fertility in obese PCOS patients with anovulatory infertility. We hypothesize that in both interventions an improvement in insulin sensitivity is the pivotal factor involved in the restoration of ovarian function but potentially acting through different mechanisms.

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