Studies in animal models and humans suggesting a role of nerve growth factor in schizophrenia-like disorders

L. Aloe, A. Iannitelli, F. Angelucci, G. Bersani, M. Fiore

Research output: Contribution to journalArticle

Abstract

Neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), are known to play a crucial role in growth, differentiation and function in a variety of brain neurons during development and in adult life. We have recently shown that environmental changes, aggressive behavior and anxiety-like responses alter both circulating and brain basal NGF levels. In the present review, we present data obtained using animal models which suggest that neurotrophic factors, particularly NGF and BDNF, might be implicated in mechanism(s) leading to a condition associated with schizophrenic-like behaviors. The hypothesis that neurotrophins of the NGF family can be implicated in some maldevelopmental aspects of schizophrenia is supported by findings indicating that the constitutive levels of NGF and BDNF are affected in schizophrenic patients. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalBehavioural Pharmacology
Volume11
Issue number3-4
Publication statusPublished - 2000

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Keywords

  • Animal models
  • Behavior
  • Brain-derived neurotrophic factor (BDNF)
  • Maldevelopment
  • Nerve growth factor
  • Neurotrophins
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

Aloe, L., Iannitelli, A., Angelucci, F., Bersani, G., & Fiore, M. (2000). Studies in animal models and humans suggesting a role of nerve growth factor in schizophrenia-like disorders. Behavioural Pharmacology, 11(3-4), 235-242.