Studies of EBV-lymphoid cell interactions in two patients with the X-linked lymphoproliferative syndrome: Normal EBV-specific HLA-restricted cytotoxicity

F. Rousset, G. Souillet, M. G. Roncarolo, J. P. Lamelin

Research output: Contribution to journalArticlepeer-review

Abstract

Two X-linked lymphoproliferative syndrome (XLP) patients with the hypogammaglobulinemia phenotype were investigated at a time remote from their primary infection with the Epstein-Barr virus (EBV). The lymphoblastoid cell lines derived from these patients expressed the phenotypic markers characteristic of normal mature B lymphocytes and produced normal levels of immunoglobulins (Ig). These observations imply that at least some of their B cells are phenotypically normal. The natural killer (NK) activity of the two patients was low. In one patient, activated lymphocyte killer (ALK) activity was inefficient. These two XLP patients expressed a normal EBV-specific. HLA-restricted cytotoxic activity. It thus appears, from the present findings and those in cases published previously (6/11 patients expressing normal EBV-specific cytotoxic activity), that the notion of poor specific T cell memory for EBV may not be as pivotal ass suggested or, alternatively, that this defect may not be common in hypogammaglobulinemic survivors.

Original languageEnglish
Pages (from-to)280-289
Number of pages10
JournalClinical and Experimental Immunology
Volume63
Issue number2
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology

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