Studies of the absorption and removal of propranolol in hypertensive patients during therapy

C. A. Chidsey, P. Morselli, G. Bianchetti, A. Morganti, G. Leonetti, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

The variability of plasma propranolol concentrations has been determined in a large group of patients being treated with the drug. Although the average patient achieved a therapeutic plasma level with 160 mg/day, there was marked interpatient variation. This was found to be primarily the result of differences in effective absorption of the drug, which averaged 46% of the oral dose but ranged from 20 to 80%. Propranolol disappeared from plasma with a half life of 4.7 hours and its removal appeared to follow dose independent kinetics with no evidence of saturation of hepatic metabolism. The derived pharmacokinetic values of volume of distribution and clearance rate have been used to provide guidelines for initiating propranolol therapy intravenously, and the schedule of 8 mg as a loading dose and 0.02 mg/min as a sustaining dose has been suggested.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalCirculation
Volume52
Issue number2
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Chidsey, C. A., Morselli, P., Bianchetti, G., Morganti, A., Leonetti, G., & Zanchetti, A. (1975). Studies of the absorption and removal of propranolol in hypertensive patients during therapy. Circulation, 52(2), 313-318.