Studies of the relationship between cell proliferation and cell death. II. Early gene expression during concanavalin A-induced proliferation or dexamethasone-induced apoptosis of rat thymocytes

E. Grassilli, A. Carcereri de Prati, D. Monti, L. Troiano, M. Menegazzi, D. Barbieri, C. Franceschi, H. Suzuki

Research output: Contribution to journalArticle

Abstract

Several data in the literature suggest that an intriguing relationship exists between cell proliferation and cell death. Accordingly, we studied the early expression of different genes in the same cells, i.e. rat thymocytes, undergoing cell proliferation upon stimulation with Concavalin A or cell death following dexamethasone treatment. We showed that an early accumulation of c-fos, c-jun and c-myc mRNA occurred in both phenomena but with different kinetics. It can be speculated that the early induction of nuclear oncogenes is necessary to allow the later induction of other genes probably regulated at the transcriptional level by the AP-1 complex and/or by Myc protein. The accumulation of the transcript for another gene, i.e. poly(ADP-ribose)polymerase, an enzyme responsable for post-translational modifications of several nuclear proteins, could instead be related to chromatin modifications occurring in both processes.

Original languageEnglish
Pages (from-to)1261-1266
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume188
Issue number3
DOIs
Publication statusPublished - Nov 16 1992

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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