Studies on anti-myelin antibodies in patients with multiple sclerosis.

E. Nobile-Orazio, G. Spagnol, R. Daverio, L. Riboni, R. Macchi, E. Francomano, G. Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the CSF and sera from 16 patients with MS to detect IgG antibody activity against normal CNS myelin and some of its proteic and lipidic components. IgG binding to a protein band of the same MW of myelin basic protein was detected by "immunoblot" in the sera and/or CSF of 25% of patients with MS and in none of the controls with OND. No IgG antibody reactivity against other components of CNS myelin was detectable in patients with MS, and immunoabsorption of the CSF of MS patients with CNS myelin did not modify the oligoclonal prophile of CSF IgG. Anti-myelin antibodies do not seem to represent the bulk of oligoclonal IgG in MS patients.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalRivista di Neurologia
Volume57
Issue number1
Publication statusPublished - Jan 1987

ASJC Scopus subject areas

  • Clinical Neurology

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