Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé

W. Kostowski, E. Giacalone, S. Garattini, L. Valzelli

Research output: Contribution to journalArticle

Abstract

Lesions of the midbrain raphé in rats produced a marked decrease of 5-HT and 5-HIAA levels in the forebrain. An increase of spontaneous motor activity and an onset of signs of abnormal behaviour were observed. A good correlation has been found between the intensity of behavioural excitation and the decrease of 5-HT and 5-HIAA in the forebrain. Bioelectrical investigations of frontal cortical activity showed a persistent arousal in EEG pattern.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalEuropean Journal of Pharmacology
Volume4
Issue number4
Publication statusPublished - Nov 1968

Fingerprint

Hydroxyindoleacetic Acid
Prosencephalon
Mesencephalon
Serotonin
Arousal
Electroencephalography
Motor Activity

Keywords

  • 5-HT and behaviour
  • 5-HT and cortical activity
  • brain 5-HT and 5-HIAA
  • midbrain raphé

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé. / Kostowski, W.; Giacalone, E.; Garattini, S.; Valzelli, L.

In: European Journal of Pharmacology, Vol. 4, No. 4, 11.1968, p. 371-376.

Research output: Contribution to journalArticle

Kostowski, W. ; Giacalone, E. ; Garattini, S. ; Valzelli, L. / Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé. In: European Journal of Pharmacology. 1968 ; Vol. 4, No. 4. pp. 371-376.
@article{c0ac8c7cc12f4ca984ef913ca15bfbad,
title = "Studies on behavioral and biochemical changes in rats after lesion of midbrain raph{\'e}",
abstract = "Lesions of the midbrain raph{\'e} in rats produced a marked decrease of 5-HT and 5-HIAA levels in the forebrain. An increase of spontaneous motor activity and an onset of signs of abnormal behaviour were observed. A good correlation has been found between the intensity of behavioural excitation and the decrease of 5-HT and 5-HIAA in the forebrain. Bioelectrical investigations of frontal cortical activity showed a persistent arousal in EEG pattern.",
keywords = "5-HT and behaviour, 5-HT and cortical activity, brain 5-HT and 5-HIAA, midbrain raph{\'e}",
author = "W. Kostowski and E. Giacalone and S. Garattini and L. Valzelli",
year = "1968",
month = "11",
language = "English",
volume = "4",
pages = "371--376",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé

AU - Kostowski, W.

AU - Giacalone, E.

AU - Garattini, S.

AU - Valzelli, L.

PY - 1968/11

Y1 - 1968/11

N2 - Lesions of the midbrain raphé in rats produced a marked decrease of 5-HT and 5-HIAA levels in the forebrain. An increase of spontaneous motor activity and an onset of signs of abnormal behaviour were observed. A good correlation has been found between the intensity of behavioural excitation and the decrease of 5-HT and 5-HIAA in the forebrain. Bioelectrical investigations of frontal cortical activity showed a persistent arousal in EEG pattern.

AB - Lesions of the midbrain raphé in rats produced a marked decrease of 5-HT and 5-HIAA levels in the forebrain. An increase of spontaneous motor activity and an onset of signs of abnormal behaviour were observed. A good correlation has been found between the intensity of behavioural excitation and the decrease of 5-HT and 5-HIAA in the forebrain. Bioelectrical investigations of frontal cortical activity showed a persistent arousal in EEG pattern.

KW - 5-HT and behaviour

KW - 5-HT and cortical activity

KW - brain 5-HT and 5-HIAA

KW - midbrain raphé

UR - http://www.scopus.com/inward/record.url?scp=0014355676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014355676&partnerID=8YFLogxK

M3 - Article

C2 - 5724914

AN - SCOPUS:0014355676

VL - 4

SP - 371

EP - 376

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 4

ER -