Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé

W. Kostowski, E. Giacalone, S. Garattini, L. Valzelli

Research output: Contribution to journalArticlepeer-review

Abstract

Lesions of the midbrain raphé in rats produced a marked decrease of 5-HT and 5-HIAA levels in the forebrain. An increase of spontaneous motor activity and an onset of signs of abnormal behaviour were observed. A good correlation has been found between the intensity of behavioural excitation and the decrease of 5-HT and 5-HIAA in the forebrain. Bioelectrical investigations of frontal cortical activity showed a persistent arousal in EEG pattern.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalEuropean Journal of Pharmacology
Volume4
Issue number4
Publication statusPublished - Nov 1968

Keywords

  • 5-HT and behaviour
  • 5-HT and cortical activity
  • brain 5-HT and 5-HIAA
  • midbrain raphé

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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