TY - JOUR
T1 - Studies on intragastric PCO2 at rest and during exercise as a marker of intestinal perfusion in patients with chronic heart failure
AU - Krack, Andreas
AU - Richartz, Barbara M.
AU - Gastmann, Anja
AU - Greim, Kasia
AU - Lotze, Ulrich
AU - Anker, Stefan D.
AU - Figulla, Hans R.
PY - 2004/6
Y1 - 2004/6
N2 - Aims: The aim of this study was to investigate mesenteric ischaemia by determining intragastric PCO2 (iPCO2) with gastric tonometry during rest and exercise stress testing in patients with chronic heart failure (CHF). In CHF inflammatory immune activation is hypothesized to result from a chronic endotoxin challenge due to bacterial translocation of hypoperfused intestinal mucosa. Methods and Results: In 10 patients with CHF and ten healthy controls a tonometry catheter was inserted into the stomach. IPCO2 was measured at rest and during bicycle exercise every 5 min. At rest arterial pCO2 (aPCO2), intragastric pCO 2 (iPCO2) and the intragastric/arterial gap did not differ between patients and controls. During low level exercise (25 W), patients showed an increase in iPCO2 compared to resting iPCO2, whereas controls did not show an increase in iPCO2 (change in iPCO2: 12±2% vs. 1±0.4%, P2 during peak exercise was 25±3% higher than at rest, compared to controls (increase 2±1, P2. This is likely to reflect hypoperfusion of the intestinal mucosa, which may contribute to the development of bacterial translocation.
AB - Aims: The aim of this study was to investigate mesenteric ischaemia by determining intragastric PCO2 (iPCO2) with gastric tonometry during rest and exercise stress testing in patients with chronic heart failure (CHF). In CHF inflammatory immune activation is hypothesized to result from a chronic endotoxin challenge due to bacterial translocation of hypoperfused intestinal mucosa. Methods and Results: In 10 patients with CHF and ten healthy controls a tonometry catheter was inserted into the stomach. IPCO2 was measured at rest and during bicycle exercise every 5 min. At rest arterial pCO2 (aPCO2), intragastric pCO 2 (iPCO2) and the intragastric/arterial gap did not differ between patients and controls. During low level exercise (25 W), patients showed an increase in iPCO2 compared to resting iPCO2, whereas controls did not show an increase in iPCO2 (change in iPCO2: 12±2% vs. 1±0.4%, P2 during peak exercise was 25±3% higher than at rest, compared to controls (increase 2±1, P2. This is likely to reflect hypoperfusion of the intestinal mucosa, which may contribute to the development of bacterial translocation.
KW - Bacterial translocation
KW - CHF, chronic heart failure
KW - Chronic heart failure
KW - Intestinal perfusion
KW - NYHA, New York Heart Association
KW - PCO, partial pressure of carbondioxide
KW - PO , partial pressure of oxygen
UR - http://www.scopus.com/inward/record.url?scp=2942564169&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942564169&partnerID=8YFLogxK
U2 - 10.1016/j.ejheart.2004.03.002
DO - 10.1016/j.ejheart.2004.03.002
M3 - Article
C2 - 15182764
AN - SCOPUS:2942564169
VL - 6
SP - 403
EP - 407
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 4
ER -