TY - JOUR
T1 - Studies on terminal deoxynucleotidyl transferase and adenosine deaminase in myasthenic thymus
AU - Vezzoni, Paolo
AU - Fiacchino, Folco
AU - Clerici, Libero
AU - Sghirlanzoni, Angelo
AU - Cerrato, Dario
AU - Peluchetti, Dionisio
AU - Lucchini, Roberto
AU - Raineri, Monica
AU - Cornelio, Ferdinando
PY - 1984
Y1 - 1984
N2 - Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both enzymes were found in young patients. The enzymatic activities were easily detectable also in the oldest patients, despite the morphological involution and the decrease in TdT which are known to occur with age in the normal thymus. TdT and ADA-containing cells were almost completely depleted in all the 3 treated patients by the corticosteroid treatment which provides a non-surgical alternative to the elimination of this lymphoid population by thymectomy. The persistence of TdT and ADA activity in old age, and their inhibition by the corticosteroid treatment.
AB - Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both enzymes were found in young patients. The enzymatic activities were easily detectable also in the oldest patients, despite the morphological involution and the decrease in TdT which are known to occur with age in the normal thymus. TdT and ADA-containing cells were almost completely depleted in all the 3 treated patients by the corticosteroid treatment which provides a non-surgical alternative to the elimination of this lymphoid population by thymectomy. The persistence of TdT and ADA activity in old age, and their inhibition by the corticosteroid treatment.
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U2 - 10.1016/0165-5728(84)90067-5
DO - 10.1016/0165-5728(84)90067-5
M3 - Article
C2 - 6480820
AN - SCOPUS:0021180783
VL - 6
SP - 427
EP - 433
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 6
ER -