Studies on the clotting mechanism of limulus polyphemus

D. Fumarola, N. Pasquetto, P. Telesforo, M. B. Donati

Research output: Contribution to journalArticlepeer-review


Several substances interacting with the clotting mechanism of mammalians were tested on lysate of Limulus hemolymphe cells. Gelation was observed in the presence of thrombin, reptilase, botropase, thrombin-coagulase and rabbit or human thromboplastin. Acidification experiments suggested that the above mentioned substances are able to activate, like endotoxin, an inactive proenzyme in the lysate to form an enzyme capable to induce the coagulogen gelation. In contrast, only trypsin would be able to transform directly the coagulogen into a gel.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalThrombosis Research
Issue number3
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology


Dive into the research topics of 'Studies on the clotting mechanism of limulus polyphemus'. Together they form a unique fingerprint.

Cite this