Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man

Vittorio Ventafridda, Mauro Blanchi, Caria Ripamonti, Paola Sacerdote, Franco De Conno, Ernesto Zecca, Alberto E. Panerai

Research output: Contribution to journalArticle

Abstract

In the rat we studied the effect of 3 tricyclic antidepressants: chlorimipramine, amitriptyline and nortriptyline, and the atypical antidepressant trazodone on pain thresholds when administered alone or together with morphine. Moreover, we evaluated the effect of the antidepressants on free morphine plasma concentrations both in the rat and in man. We observed that chlorimipramine and amitriptyline, two tricyclic antidepressants active on the serotoninergic system, induce analgesia and potentiate morphine analgesia in a dose-related fashion. The noradrenergic tricyclic nortriptyline and trazodone did not elicit analgesia and inconsistently affected morphine analgesia. In the rat, all drugs tested increased plasma concentrations of morphine with the exception of amitriptyline. In man, only chlorimipramine and amitriptyline increased the plasma concentration of the free opiate.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalPain
Volume43
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • Analgesia
  • Antidepressants
  • Morphine

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

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