Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog

Franco Rengo, Massimo Chiariello, Lorenzo de Caprio, Luigi Saccà, Bruno Trimarco, Gavino Perez, Mario Condorelli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of electrostimulation of the cephalic endings of the vagosympathetic trunks on the systemic and perfusion pressure of the hind limb of the dog depend upon frequency, intensity and duration of the stimulus. The electro-stimulation performed with stimuli of high frequency, low intensity and moderately long duration (rectangular waves of 1.5 V, 0.7 msec, 100 Hz) consistently elicited systemic hypertension and vasoconstriction. This response was completely abolished by pretreatment with guanethidine or hexamethonium. On the other hand, electrostimulation with stimuli of low frequency, high intensity and long duration (5 V, 1 msec, 10 Hz) produced systcmic hypotension and vasodilatation in the perfused hind limb. These effects were completely blocked by atropine or hexamethonium, while guanethidine was unable to induce any modification. These findings suggest that electrostimulation of vagosympathetic trunks can evoke different hemodynamic responses depending upon the characteristics of the stimulus. The occurrence of a vasodilatation specifically blocked by atropine demonstrates that a purely cholinergic mechanism underlies such a reflex response.

Original languageEnglish
Pages (from-to)98-112
Number of pages15
JournalCardiology
Volume60
Issue number2
DOIs
Publication statusPublished - 1975

Fingerprint

Guanethidine
Hexamethonium
Atropine
Vasodilation
Electric Stimulation
Extremities
Hemodynamics
Dogs
Vasoconstriction
Hypotension
Cholinergic Agents
Reflex
Perfusion
Head
Hypertension
Pressure

Keywords

  • Atropine
  • Guanethidine
  • Hexamethonium
  • Perfused dog hindlimb
  • Reflex vasodilatation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Rengo, F., Chiariello, M., de Caprio, L., Saccà, L., Trimarco, B., Perez, G., & Condorelli, M. (1975). Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog. Cardiology, 60(2), 98-112. https://doi.org/10.1159/000169708

Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog. / Rengo, Franco; Chiariello, Massimo; de Caprio, Lorenzo; Saccà, Luigi; Trimarco, Bruno; Perez, Gavino; Condorelli, Mario.

In: Cardiology, Vol. 60, No. 2, 1975, p. 98-112.

Research output: Contribution to journalArticle

Rengo, F, Chiariello, M, de Caprio, L, Saccà, L, Trimarco, B, Perez, G & Condorelli, M 1975, 'Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog', Cardiology, vol. 60, no. 2, pp. 98-112. https://doi.org/10.1159/000169708
Rengo, Franco ; Chiariello, Massimo ; de Caprio, Lorenzo ; Saccà, Luigi ; Trimarco, Bruno ; Perez, Gavino ; Condorelli, Mario. / Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog. In: Cardiology. 1975 ; Vol. 60, No. 2. pp. 98-112.
@article{0da36d3f2c05444dbb0a5e2341929adb,
title = "Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog",
abstract = "The effects of electrostimulation of the cephalic endings of the vagosympathetic trunks on the systemic and perfusion pressure of the hind limb of the dog depend upon frequency, intensity and duration of the stimulus. The electro-stimulation performed with stimuli of high frequency, low intensity and moderately long duration (rectangular waves of 1.5 V, 0.7 msec, 100 Hz) consistently elicited systemic hypertension and vasoconstriction. This response was completely abolished by pretreatment with guanethidine or hexamethonium. On the other hand, electrostimulation with stimuli of low frequency, high intensity and long duration (5 V, 1 msec, 10 Hz) produced systcmic hypotension and vasodilatation in the perfused hind limb. These effects were completely blocked by atropine or hexamethonium, while guanethidine was unable to induce any modification. These findings suggest that electrostimulation of vagosympathetic trunks can evoke different hemodynamic responses depending upon the characteristics of the stimulus. The occurrence of a vasodilatation specifically blocked by atropine demonstrates that a purely cholinergic mechanism underlies such a reflex response.",
keywords = "Atropine, Guanethidine, Hexamethonium, Perfused dog hindlimb, Reflex vasodilatation",
author = "Franco Rengo and Massimo Chiariello and {de Caprio}, Lorenzo and Luigi Sacc{\`a} and Bruno Trimarco and Gavino Perez and Mario Condorelli",
year = "1975",
doi = "10.1159/000169708",
language = "English",
volume = "60",
pages = "98--112",
journal = "Cardiology",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Studies on the hemodynamic changes induced by electrical stimulation of the vagosympathetic trunks in the dog

AU - Rengo, Franco

AU - Chiariello, Massimo

AU - de Caprio, Lorenzo

AU - Saccà, Luigi

AU - Trimarco, Bruno

AU - Perez, Gavino

AU - Condorelli, Mario

PY - 1975

Y1 - 1975

N2 - The effects of electrostimulation of the cephalic endings of the vagosympathetic trunks on the systemic and perfusion pressure of the hind limb of the dog depend upon frequency, intensity and duration of the stimulus. The electro-stimulation performed with stimuli of high frequency, low intensity and moderately long duration (rectangular waves of 1.5 V, 0.7 msec, 100 Hz) consistently elicited systemic hypertension and vasoconstriction. This response was completely abolished by pretreatment with guanethidine or hexamethonium. On the other hand, electrostimulation with stimuli of low frequency, high intensity and long duration (5 V, 1 msec, 10 Hz) produced systcmic hypotension and vasodilatation in the perfused hind limb. These effects were completely blocked by atropine or hexamethonium, while guanethidine was unable to induce any modification. These findings suggest that electrostimulation of vagosympathetic trunks can evoke different hemodynamic responses depending upon the characteristics of the stimulus. The occurrence of a vasodilatation specifically blocked by atropine demonstrates that a purely cholinergic mechanism underlies such a reflex response.

AB - The effects of electrostimulation of the cephalic endings of the vagosympathetic trunks on the systemic and perfusion pressure of the hind limb of the dog depend upon frequency, intensity and duration of the stimulus. The electro-stimulation performed with stimuli of high frequency, low intensity and moderately long duration (rectangular waves of 1.5 V, 0.7 msec, 100 Hz) consistently elicited systemic hypertension and vasoconstriction. This response was completely abolished by pretreatment with guanethidine or hexamethonium. On the other hand, electrostimulation with stimuli of low frequency, high intensity and long duration (5 V, 1 msec, 10 Hz) produced systcmic hypotension and vasodilatation in the perfused hind limb. These effects were completely blocked by atropine or hexamethonium, while guanethidine was unable to induce any modification. These findings suggest that electrostimulation of vagosympathetic trunks can evoke different hemodynamic responses depending upon the characteristics of the stimulus. The occurrence of a vasodilatation specifically blocked by atropine demonstrates that a purely cholinergic mechanism underlies such a reflex response.

KW - Atropine

KW - Guanethidine

KW - Hexamethonium

KW - Perfused dog hindlimb

KW - Reflex vasodilatation

UR - http://www.scopus.com/inward/record.url?scp=0016768629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016768629&partnerID=8YFLogxK

U2 - 10.1159/000169708

DO - 10.1159/000169708

M3 - Article

C2 - 1182719

AN - SCOPUS:0016768629

VL - 60

SP - 98

EP - 112

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 2

ER -