Abstract
Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.
| Original language | English |
|---|---|
| Pages (from-to) | 217-223 |
| Number of pages | 7 |
| Journal | Brain Research |
| Volume | 225 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 23 1981 |
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Keywords
- acetylcholine
- diarrhea
- dopamine
- noradrenaline
- oxotremorine
- serotonin
- striatum
- tremor
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum. / Ladinsky, Herbert; Consolo, Silvana; Forloni, Gianluigi; Tirelli, Amedea Silvia.
In: Brain Research, Vol. 225, No. 1, 23.11.1981, p. 217-223.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum
AU - Ladinsky, Herbert
AU - Consolo, Silvana
AU - Forloni, Gianluigi
AU - Tirelli, Amedea Silvia
PY - 1981/11/23
Y1 - 1981/11/23
N2 - Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.
AB - Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.
KW - acetylcholine
KW - diarrhea
KW - dopamine
KW - noradrenaline
KW - oxotremorine
KW - serotonin
KW - striatum
KW - tremor
UR - http://www.scopus.com/inward/record.url?scp=0019510234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019510234&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(81)90334-6
DO - 10.1016/0006-8993(81)90334-6
M3 - Article
C2 - 7296277
AN - SCOPUS:0019510234
VL - 225
SP - 217
EP - 223
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -