Abstract
Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.
Original language | English |
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Pages (from-to) | 217-223 |
Number of pages | 7 |
Journal | Brain Research |
Volume | 225 |
Issue number | 1 |
DOIs | |
Publication status | Published - Nov 23 1981 |
Keywords
- acetylcholine
- diarrhea
- dopamine
- noradrenaline
- oxotremorine
- serotonin
- striatum
- tremor
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)