Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum

Herbert Ladinsky, Silvana Consolo, Gianluigi Forloni, Amedea Silvia Tirelli

Research output: Contribution to journalArticlepeer-review

Abstract

Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalBrain Research
Volume225
Issue number1
DOIs
Publication statusPublished - Nov 23 1981

Keywords

  • acetylcholine
  • diarrhea
  • dopamine
  • noradrenaline
  • oxotremorine
  • serotonin
  • striatum
  • tremor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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