Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum

Herbert Ladinsky; Silvana Consolo; Gianluigi Forloni; Amedea Silvia Tirelli

doi:10.1016/0006-8993(81)90334-6

Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum

Herbert Ladinsky, Silvana Consolo, Gianluigi Forloni, Amedea Silvia Tirelli

Research output: Contribution to journal › Article › peer-review

Abstract

Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.

Original language	English
Pages (from-to)	217-223
Number of pages	7
Journal	Brain Research
Volume	225
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)90334-6
Publication status	Published - Nov 23 1981

Keywords

acetylcholine
diarrhea
dopamine
noradrenaline
oxotremorine
serotonin
striatum
tremor

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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abstract = "Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.",

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AU - Consolo, Silvana

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AB - Oxotremorine produced 30-75% increases in rat striatal acetylcholine content and 10-15% decreases in choline content at the subtremorogenic doses of 0.34-1.34 μmol/kg, without affecting choline acetyltransferase and acetylcholinesterase activities and the sodium-dependent high affinity uptake of choline. The increases in acetylcholine was blocked by atropine and by reserpine indicating that oxotremorine indirectly influences the intrinsic striatal cholinergic neurons through a monoamine-mediated negative feedback loop. Experiments designed to interfere with neurotransmitter function indicated that noradrenaline and not dopamine or serotonin, mediated the response to oxotremorine.

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Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum

Abstract

Keywords

ASJC Scopus subject areas

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