Studies on the mechanism of salicylate-induced increase of insulin secretion in man

D. Giugliano, D. Cozzolino, A. Ceriello, T. Cerciello, R. Varano, F. Saccomanno, R. Torella

Research output: Contribution to journalArticle

Abstract

Salicylate compounds are known to increase basal and stimulated insulin secretion in man. In our studies, infusion of lysine acetylsalicylate (72 mg/min) increased basal insulin levels and amplified insulin responses to glucose (5 g i.v.), arginine (5 g i.v.) and tolbutamide (1 g i.v.) Verapamil, an organic calcium antagonist, dit not modify LAS-induced increase of basal insulin levels, but reduced the effect of LAS on glucose-induced insulin secretion. Calcitonin and somatostatin, two agents that inhibit basal and glucose-stimulated insulin secretion, inhibited the insulin response to glucose in presence of LAS infusion. The ability of salicylate compounds to augment insulin secretion might be due to multiple sites of action in the Beta-cells.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalDiabete et Metabolisme
Volume14
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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    Giugliano, D., Cozzolino, D., Ceriello, A., Cerciello, T., Varano, R., Saccomanno, F., & Torella, R. (1988). Studies on the mechanism of salicylate-induced increase of insulin secretion in man. Diabete et Metabolisme, 14(4), 431-436.