Studies on the retina of the diabetic db/db mouse: I. endothelial cell-pericyte ratio

Edoardo Midena, Tatiana Segato, Sandra Radin, Giuseppe Di Giorgio, Francesca Meneghini, Stefano Piermarocchi, Anna S. Belloni

Research output: Contribution to journalArticle

Abstract

The genetically diabetic db/db mouse is a model of type-2 diabetes, where nephropathy and neuropathy, but not retinopathy were observed. The authors studied the retinas (trypsin digestion technique) of 16 db/db mice and 16 age-matched litter mates (db/m; controls), divided into five age groups. They noted a marked increase in the ratio of endothelial cells to intramural pericytes in diabetic mice compared to controls. This increase resulted from a selective and highly significant loss of pericytes in db/db mice (p <0.05). Some strand-like and relatively acellular capillaries were also observed. The db/db mouse may represent an adequate model for studies on the pathogenesis of retinopathy.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalOphthalmic Research
Volume21
Issue number2
DOIs
Publication statusPublished - 1989

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Pericytes
Retina
Endothelial Cells
Trypsin
Type 2 Diabetes Mellitus
Digestion
Age Groups

Keywords

  • Animal models
  • Db/db mouse
  • Diabetes
  • Diabetic retinopathy
  • Retinal capillaries

ASJC Scopus subject areas

  • Ophthalmology
  • Cellular and Molecular Neuroscience
  • Sensory Systems

Cite this

Midena, E., Segato, T., Radin, S., Di Giorgio, G., Meneghini, F., Piermarocchi, S., & Belloni, A. S. (1989). Studies on the retina of the diabetic db/db mouse: I. endothelial cell-pericyte ratio. Ophthalmic Research, 21(2), 106-111. https://doi.org/10.1159/000266787

Studies on the retina of the diabetic db/db mouse : I. endothelial cell-pericyte ratio. / Midena, Edoardo; Segato, Tatiana; Radin, Sandra; Di Giorgio, Giuseppe; Meneghini, Francesca; Piermarocchi, Stefano; Belloni, Anna S.

In: Ophthalmic Research, Vol. 21, No. 2, 1989, p. 106-111.

Research output: Contribution to journalArticle

Midena, E, Segato, T, Radin, S, Di Giorgio, G, Meneghini, F, Piermarocchi, S & Belloni, AS 1989, 'Studies on the retina of the diabetic db/db mouse: I. endothelial cell-pericyte ratio', Ophthalmic Research, vol. 21, no. 2, pp. 106-111. https://doi.org/10.1159/000266787
Midena, Edoardo ; Segato, Tatiana ; Radin, Sandra ; Di Giorgio, Giuseppe ; Meneghini, Francesca ; Piermarocchi, Stefano ; Belloni, Anna S. / Studies on the retina of the diabetic db/db mouse : I. endothelial cell-pericyte ratio. In: Ophthalmic Research. 1989 ; Vol. 21, No. 2. pp. 106-111.
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