Studies on the retina of the diabetic db/db mouse: I. endothelial cell-pericyte ratio

Edoardo Midena, Tatiana Segato, Sandra Radin, Giuseppe Di Giorgio, Francesca Meneghini, Stefano Piermarocchi, Anna S. Belloni

Research output: Contribution to journalArticlepeer-review

Abstract

The genetically diabetic db/db mouse is a model of type-2 diabetes, where nephropathy and neuropathy, but not retinopathy were observed. The authors studied the retinas (trypsin digestion technique) of 16 db/db mice and 16 age-matched litter mates (db/m; controls), divided into five age groups. They noted a marked increase in the ratio of endothelial cells to intramural pericytes in diabetic mice compared to controls. This increase resulted from a selective and highly significant loss of pericytes in db/db mice (p <0.05). Some strand-like and relatively acellular capillaries were also observed. The db/db mouse may represent an adequate model for studies on the pathogenesis of retinopathy.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalOphthalmic Research
Volume21
Issue number2
DOIs
Publication statusPublished - 1989

Keywords

  • Animal models
  • Db/db mouse
  • Diabetes
  • Diabetic retinopathy
  • Retinal capillaries

ASJC Scopus subject areas

  • Ophthalmology
  • Cellular and Molecular Neuroscience
  • Sensory Systems

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