Studies on the role of 5-HT receptors in satiation and the effect of d-fenfluramine in the runway test

Joanna C. Neill, Caterina Bendotti, Rosario Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

d-Fenfluramine has previously been shown to reduce food-rewarded runway behaviour in the rat, an effect thought to be mediated through activation of central 5-HT pathways. We now examined in more detail the mechanism by which d-fenfluramine reduces runway performance and food intake in the 15-trial runway test. The non-selective 5-HT receptor antagonist, metergoline (1.0 mg/kg), significantly antagonised the effect of d-fenfluramine (2.5 mg/kg) in the runway test. In contrast, neither ritanserin, the potent 5-HT2 and 5-HT1c receptor antagonist (0.5 mg/kg), nor the peripheral 5-HT receptor antagonist, xylainidine (3.0 mg/kg), attenuated the effect of d-fenfluramine in this lest situation. Metergoline, but not ritanserin or xylamidine significantly increased runway performance when administered alone. These data indicate that d-fenfluramine reduces runway performance and food intake through activation of 5-HT1 receptors. In addition, blockade of 5-HT1 receptors can attenuate the development of satiation normally observed under control conditions in the runway test.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalEuropean Journal of Pharmacology
Volume190
Issue number1-2
DOIs
Publication statusPublished - Nov 6 1990

Keywords

  • 5-HT receptors (central)
  • D-Fenfluramine
  • Food intake
  • Runway performance

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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