Abstract
Acebrofilline (AC) is obtained by the salification of a molecule of ambroxol hydrochloride (AM) and one of teofillin-7-acetic acid. It stimulates the synthesis and secretion of pulmonary surfactant. This one has recently been shown to have a very similar synthesis pathway to that of the phospholipid mediators of inflammation. The aim of our study was to compare the anti-inflammatory action of AC with that of AM. These studies were performed using histological examinations as well as by measuring (by RIA) the changes in leukotriene (LTB4) and thromboxane (TXB2) levels. These assaies were carried out on 360 guinea-pigs (in which inflammation had been induced by intravenous administration of oleic acid), after they received AC or AM either on a prophylactic or therapeutic regimen. The results showed a marked decrease in pulmonary inflammation in guinea-pigs treated with AC and AM with respect to the guinea-pigs which had not been treated at all. Furthermore, in the animals treated with AC, the values returned to normal in a shorter time than for those treated with AM. These results were statistically significant, and were further confirmed by the histological examination.
| Original language | English |
|---|---|
| Pages (from-to) | 73-78 |
| Number of pages | 6 |
| Journal | GIMT - Giornale Italiano delle Malattie del Torace |
| Volume | 48 |
| Issue number | 3-4 |
| Publication status | Published - 1994 |
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Keywords
- Leukotriene
- Pulmonary inflammation in animal model
- Thromboxane
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
STUDIO COMPARATIVO DI ACEBROFILLINA ED AMBROXOL CLORIDRATO IN CAVIE CON INFIAMMAZIONE POLMONARE ACUTA. / Gismondo, M. R.; Lombardi, A.; Fassina, C.; Drago, L.
In: GIMT - Giornale Italiano delle Malattie del Torace, Vol. 48, No. 3-4, 1994, p. 73-78.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - STUDIO COMPARATIVO DI ACEBROFILLINA ED AMBROXOL CLORIDRATO IN CAVIE CON INFIAMMAZIONE POLMONARE ACUTA
AU - Gismondo, M. R.
AU - Lombardi, A.
AU - Fassina, C.
AU - Drago, L.
PY - 1994
Y1 - 1994
N2 - Acebrofilline (AC) is obtained by the salification of a molecule of ambroxol hydrochloride (AM) and one of teofillin-7-acetic acid. It stimulates the synthesis and secretion of pulmonary surfactant. This one has recently been shown to have a very similar synthesis pathway to that of the phospholipid mediators of inflammation. The aim of our study was to compare the anti-inflammatory action of AC with that of AM. These studies were performed using histological examinations as well as by measuring (by RIA) the changes in leukotriene (LTB4) and thromboxane (TXB2) levels. These assaies were carried out on 360 guinea-pigs (in which inflammation had been induced by intravenous administration of oleic acid), after they received AC or AM either on a prophylactic or therapeutic regimen. The results showed a marked decrease in pulmonary inflammation in guinea-pigs treated with AC and AM with respect to the guinea-pigs which had not been treated at all. Furthermore, in the animals treated with AC, the values returned to normal in a shorter time than for those treated with AM. These results were statistically significant, and were further confirmed by the histological examination.
AB - Acebrofilline (AC) is obtained by the salification of a molecule of ambroxol hydrochloride (AM) and one of teofillin-7-acetic acid. It stimulates the synthesis and secretion of pulmonary surfactant. This one has recently been shown to have a very similar synthesis pathway to that of the phospholipid mediators of inflammation. The aim of our study was to compare the anti-inflammatory action of AC with that of AM. These studies were performed using histological examinations as well as by measuring (by RIA) the changes in leukotriene (LTB4) and thromboxane (TXB2) levels. These assaies were carried out on 360 guinea-pigs (in which inflammation had been induced by intravenous administration of oleic acid), after they received AC or AM either on a prophylactic or therapeutic regimen. The results showed a marked decrease in pulmonary inflammation in guinea-pigs treated with AC and AM with respect to the guinea-pigs which had not been treated at all. Furthermore, in the animals treated with AC, the values returned to normal in a shorter time than for those treated with AM. These results were statistically significant, and were further confirmed by the histological examination.
KW - Leukotriene
KW - Pulmonary inflammation in animal model
KW - Thromboxane
UR - http://www.scopus.com/inward/record.url?scp=0028672439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028672439&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028672439
VL - 48
SP - 73
EP - 78
JO - GIMT - Giornale Italiano delle Malattie del Torace
JF - GIMT - Giornale Italiano delle Malattie del Torace
SN - 1127-0810
IS - 3-4
ER -