STUDIO COMPARATIVO DI ACEBROFILLINA ED AMBROXOL CLORIDRATO IN CAVIE CON INFIAMMAZIONE POLMONARE ACUTA

M. R. Gismondo, A. Lombardi, C. Fassina, L. Drago

Research output: Contribution to journalArticlepeer-review

Abstract

Acebrofilline (AC) is obtained by the salification of a molecule of ambroxol hydrochloride (AM) and one of teofillin-7-acetic acid. It stimulates the synthesis and secretion of pulmonary surfactant. This one has recently been shown to have a very similar synthesis pathway to that of the phospholipid mediators of inflammation. The aim of our study was to compare the anti-inflammatory action of AC with that of AM. These studies were performed using histological examinations as well as by measuring (by RIA) the changes in leukotriene (LTB4) and thromboxane (TXB2) levels. These assaies were carried out on 360 guinea-pigs (in which inflammation had been induced by intravenous administration of oleic acid), after they received AC or AM either on a prophylactic or therapeutic regimen. The results showed a marked decrease in pulmonary inflammation in guinea-pigs treated with AC and AM with respect to the guinea-pigs which had not been treated at all. Furthermore, in the animals treated with AC, the values returned to normal in a shorter time than for those treated with AM. These results were statistically significant, and were further confirmed by the histological examination.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalGIMT - Giornale Italiano delle Malattie del Torace
Volume48
Issue number3-4
Publication statusPublished - 1994

Keywords

  • Leukotriene
  • Pulmonary inflammation in animal model
  • Thromboxane

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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