Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes.

A. Poletti, R. Manconi, R. Volpe, A. Carbone

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Salivary gland lymph node involvement is rare in patients at risk for AIDS. Intraparotid and perisubmaxillary gland lymph node biopsies from 2 intravenous drug abusers serologically positive for human immunodeficiency virus (HIV) affected by persistent generalized lymphadenopathy (PGL) were also analyzed immunohistologically. We found hypervascular reactive lymphoid hyperplasia with prevalence of suppressor T-cells within follicular centers often lacking surface IgD-positive mantle zone cells and showing disruption of the network of dendritic reticulum cells revealed with DRC-1 and anti-S-100 protein antibodies. Within the nodes there were numerous cysts lined by metaplastic squamous epithelium/positive for epithelial membrane antigen and containing numerous lymphocytes positive for leukocyte common antigen, macrophages positive for alpha 1 -antichymotrypsin, and Langerhans cells positive for OKT6. Salivary gland lymph nodes are immunohistologically similar to those of other sites in PGL and their increased epithelial metaplastic component containing cells involved in the immune response might represent an exuberant reaction to HIV infection.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalJournal of Oral Pathology
Volume17
Issue number4
Publication statusPublished - Apr 1988

Fingerprint

Acquired Immunodeficiency Syndrome
Lymph Nodes
Salivary Glands
alpha 1-Antichymotrypsin
HIV
Pseudolymphoma
CD45 Antigens
Immunoglobulin D
Mucin-1
Reticulum
Langerhans Cells
S100 Proteins
Virus Diseases
Cellular Structures
Drug Users
Dendritic Cells
Cysts
Epithelium
Macrophages
Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes. / Poletti, A.; Manconi, R.; Volpe, R.; Carbone, A.

In: Journal of Oral Pathology, Vol. 17, No. 4, 04.1988, p. 164-167.

Research output: Contribution to journalArticle

Poletti, A, Manconi, R, Volpe, R & Carbone, A 1988, 'Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes.', Journal of Oral Pathology, vol. 17, no. 4, pp. 164-167.
Poletti, A. ; Manconi, R. ; Volpe, R. ; Carbone, A. / Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes. In: Journal of Oral Pathology. 1988 ; Vol. 17, No. 4. pp. 164-167.
@article{ebd106e9636a4394953e701fab482c9e,
title = "Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes.",
abstract = "Salivary gland lymph node involvement is rare in patients at risk for AIDS. Intraparotid and perisubmaxillary gland lymph node biopsies from 2 intravenous drug abusers serologically positive for human immunodeficiency virus (HIV) affected by persistent generalized lymphadenopathy (PGL) were also analyzed immunohistologically. We found hypervascular reactive lymphoid hyperplasia with prevalence of suppressor T-cells within follicular centers often lacking surface IgD-positive mantle zone cells and showing disruption of the network of dendritic reticulum cells revealed with DRC-1 and anti-S-100 protein antibodies. Within the nodes there were numerous cysts lined by metaplastic squamous epithelium/positive for epithelial membrane antigen and containing numerous lymphocytes positive for leukocyte common antigen, macrophages positive for alpha 1 -antichymotrypsin, and Langerhans cells positive for OKT6. Salivary gland lymph nodes are immunohistologically similar to those of other sites in PGL and their increased epithelial metaplastic component containing cells involved in the immune response might represent an exuberant reaction to HIV infection.",
author = "A. Poletti and R. Manconi and R. Volpe and A. Carbone",
year = "1988",
month = "4",
language = "English",
volume = "17",
pages = "164--167",
journal = "Journal of Oral Pathology",
issn = "0300-9777",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes.

AU - Poletti, A.

AU - Manconi, R.

AU - Volpe, R.

AU - Carbone, A.

PY - 1988/4

Y1 - 1988/4

N2 - Salivary gland lymph node involvement is rare in patients at risk for AIDS. Intraparotid and perisubmaxillary gland lymph node biopsies from 2 intravenous drug abusers serologically positive for human immunodeficiency virus (HIV) affected by persistent generalized lymphadenopathy (PGL) were also analyzed immunohistologically. We found hypervascular reactive lymphoid hyperplasia with prevalence of suppressor T-cells within follicular centers often lacking surface IgD-positive mantle zone cells and showing disruption of the network of dendritic reticulum cells revealed with DRC-1 and anti-S-100 protein antibodies. Within the nodes there were numerous cysts lined by metaplastic squamous epithelium/positive for epithelial membrane antigen and containing numerous lymphocytes positive for leukocyte common antigen, macrophages positive for alpha 1 -antichymotrypsin, and Langerhans cells positive for OKT6. Salivary gland lymph nodes are immunohistologically similar to those of other sites in PGL and their increased epithelial metaplastic component containing cells involved in the immune response might represent an exuberant reaction to HIV infection.

AB - Salivary gland lymph node involvement is rare in patients at risk for AIDS. Intraparotid and perisubmaxillary gland lymph node biopsies from 2 intravenous drug abusers serologically positive for human immunodeficiency virus (HIV) affected by persistent generalized lymphadenopathy (PGL) were also analyzed immunohistologically. We found hypervascular reactive lymphoid hyperplasia with prevalence of suppressor T-cells within follicular centers often lacking surface IgD-positive mantle zone cells and showing disruption of the network of dendritic reticulum cells revealed with DRC-1 and anti-S-100 protein antibodies. Within the nodes there were numerous cysts lined by metaplastic squamous epithelium/positive for epithelial membrane antigen and containing numerous lymphocytes positive for leukocyte common antigen, macrophages positive for alpha 1 -antichymotrypsin, and Langerhans cells positive for OKT6. Salivary gland lymph nodes are immunohistologically similar to those of other sites in PGL and their increased epithelial metaplastic component containing cells involved in the immune response might represent an exuberant reaction to HIV infection.

UR - http://www.scopus.com/inward/record.url?scp=0023987498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023987498&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 164

EP - 167

JO - Journal of Oral Pathology

JF - Journal of Oral Pathology

SN - 0300-9777

IS - 4

ER -