Studio della distensibilità arteriosa nell'uomo. Quali i meccanismi di modulazione, come varia in condizioni patologiche ed effetto della terapia

Translated title of the contribution: Study of arterial distensibility in humans. Some mechanisms of modulation, such as changes in pathological conditions and effect of therapy

Cristina Giannattasio, Monica Failla, Davide Corsi, Anna Capra, Ester Meles, Gaetano Gentile, Elena Fantini, Lucia Boffi, Silvia Maestroni, Valentina Scotti, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

The reduction of large arterial distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence we have obtained by measuring distensibility through quantification of changes in arterial diameter vs blood pressure changes at large elastic and middle size muscle artery sites. Evidence shows that arterial distensibility is reduced in conditions such as hypercholesterolemia, hypertension, diabetes, and congestive heart failure. In some conditions (e.g. hypertension) the alterations are not uniformly distributed in the arteries of different structure and size whereas in others (e.g. diabetes and heart failure) they are widespread. In diabetes evidence is available that distensibility changes occur early in the course of the disease. Evidence is also available that in all above conditions treatment can improve arterial distensibility thereby reversing the initial abnormality. This is due to a variable combination of structural and functional factors. However, technical ability to determine their precise role in distensibility changes in humans is limited.

Translated title of the contributionStudy of arterial distensibility in humans. Some mechanisms of modulation, such as changes in pathological conditions and effect of therapy
Original languageItalian
Pages (from-to)467-476
Number of pages10
JournalItalian Heart Journal Supplement
Volume4
Issue number6
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Giannattasio, C., Failla, M., Corsi, D., Capra, A., Meles, E., Gentile, G., Fantini, E., Boffi, L., Maestroni, S., Scotti, V., & Mancia, G. (2003). Studio della distensibilità arteriosa nell'uomo. Quali i meccanismi di modulazione, come varia in condizioni patologiche ed effetto della terapia. Italian Heart Journal Supplement, 4(6), 467-476.