Calcium excretion and absorption were evaluated in hypercalciuric calcium stone formers by the study of Sr2+ excretion and absorption after an oral load. Ca2+ stone formers (n = 140) were studied, and the results were compared in the 83 of them who had idiopathic hypercalciuria and in the 57 who had Ca2+ excretion within reference values. Hypecalciuric patients showed increased renal Sr2+ clearance (CR(E); 5.26 ± 0.358 vs 3.29 ± 0.277 mL/min; P 2+ absorption [assessed as the area under the serum concentration-time curve (AUC)] was increased at 30 and 60 min (1.53 ± 0.087 vs 1.21 ± 0.071 mmol · L-1 · min; P 2+ fractional excretion (P 2+ load tests suggest that in the hypercalciuric population, Ca2+ absorption is altered predominantly in the doudenum and that the normal regulaion exerted by calciotropic hormones on tubular and enteral Ca2+ handling is lost.
|Number of pages||5|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Clinical Biochemistry