Study of endocrinological functions and sexual behaviour in carbon disulphide workers

A. M. Cirla, P. A. Bertazzi, M. Tomasini, A. Villa, C. Graziano, R. Invernizzi, R. Gilioli

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Thyroid function has been investigated on groups of workers with different exposure to CS 2 and in control subjects by means of conjugated thyroxine blood level, PBG activity or T 3-Test, and free thyroxine blood level. Sexual hormones have been evaluated by determining LH, FSH and Testosterone blood level; PRL has been also studied. Sexual behaviour has been studied using a questionnaire. Our data suggest that: thyroxine level is reduced in relation with the exposure and direct alterations of PBG activity in the exposed subjects seems to be present; LH and FSH are significantly reduced in the exposed subjects, while testosterone is not; and LH and FSH seem to be reduced especially during the first period of exposure even to low levels. Further on in the body it is likely that compensatory mechanisms take place; sexual activity is significantly reduced in the exposed without any definite correlation with hormonal deficit. These data confirm a primary action of CS 2 on hypophyseal activity. This hypothesis is supported also by the decrease of PRL in relation to exposure. After discontinuing a heavy exposure, important alterations of hormonal balance do not seem to persist, while sexual activity may remain reduced.

Original languageEnglish
Pages (from-to)118-129
Number of pages12
JournalMedicina del Lavoro
Issue number2
Publication statusPublished - 1978


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Cirla, A. M., Bertazzi, P. A., Tomasini, M., Villa, A., Graziano, C., Invernizzi, R., & Gilioli, R. (1978). Study of endocrinological functions and sexual behaviour in carbon disulphide workers. Medicina del Lavoro, 69(2), 118-129.