Study of functional and biochemical indicators of subclinical lung damage in bleomycin-treated patients

F. Villani, L. Bacchella, A. Bulgheroni, L. Pizzini, M. Galimberti, C. Aprile, M. Luisetti

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Abstract

In 30 patients affected by testicular non-seminomatous cancer we evaluated pulmonary function tests before and after bleomycin-including combination chemotherapy. We paid particular attention to changes in diffusing lung capacity (DCO) and its two components, namely diffusing capacity of the alveolar-capillary membrane (Dm) and pulmonary capillary blood volume (Vc). In the same patients we also evaluated the behaviour of serum procollagen III aminopeptide (sP-III-P), assumed to be a biochemical equivalent to Dm, and of serum angiotensin converting enzyme (S-ACE), assumed to be a biochemical equivalent to Vc. We found that, after chemotherapy, patients showed a significant decline in several pulmonary function parameters, namely VC, TLC, and FEV 1 (P2=0.112; P

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalRespiratory Medicine
Volume86
Issue number4
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Villani, F., Bacchella, L., Bulgheroni, A., Pizzini, L., Galimberti, M., Aprile, C., & Luisetti, M. (1992). Study of functional and biochemical indicators of subclinical lung damage in bleomycin-treated patients. Respiratory Medicine, 86(4), 327-333.