Etude des gangliosides chez les Souris normales (C57B1/6J) et Quaking. Présence et caractérisation d'un ganglioside labile en milieu alcalin.

Translated title of the contribution: Study of gangliosides in normal (C57B1/6J) and quaking mice. Presence and characterization of a labile ganglioside in alkaline solution

N. Baumann, S. Sonnino, R. Ghidoni, M. L. Harpin, G. Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

In the adult Quaking mutant, there is an increase in some polysialogangliosides (GT1 and Gq) and a 50% decrease in BM1 content. Thus, the latter ganglioside, which is a constituent of mature myelin, could be linked to one of the late steps of the myelination process. A novel ganglioside ALG1, which appears during the postnatal development of brain, has been isolated and purified; it contains an alkali labile linkage and after alkaline treatment yields GT1b. Comparison between normal Mice and Quaking mutants does not show any significant quantitative differences, under our conditions. At the stage at which it appears, it could be linked to steps of brain maturation other than myelimation.

Translated title of the contributionStudy of gangliosides in normal (C57B1/6J) and quaking mice. Presence and characterization of a labile ganglioside in alkaline solution
Original languageFrench
Pages (from-to)1807-1810
Number of pages4
JournalComptes rendus hebdomadaires des seances de l"Academie des sciences. Serie D: Sciences naturelles
Volume286
Issue number24
Publication statusPublished - Jun 19 1978

ASJC Scopus subject areas

  • Medicine(all)

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