Study of proton spin-lattice relaxation variation induced by paramagnetic antibodies

M. A. Macri, F. De Luca, B. Maraviglia, F. Polizio, G. Garreffa, S. Cavallo, P. G. Natali

Research output: Contribution to journalArticlepeer-review


A murine anti-human melanoma monoclonal antibody fragment was labeled with gadolinium and its proton relaxation efficiency compared to controls at frequencies ranging from 2 to 300 MHz. Relaxation time variations were about 30-40% in 10-15 μM solutions. The labeled fragment showed proton relaxation enhancement relative to free gadolinium, while preserving its immunoreactivity. A tentative labeling of a melanoma pellet by means of the fragment, just at the borderline of a minimum expected T1 variation, gave no detectable difference.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalMagnetic Resonance in Medicine
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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