Study of release of eosinophil cationic proteins (ECP and EPX) in the hypereosinophilic syndrome (HES) and other hypereosinophilic conditions

E. Bobbio-Pallavicini, M. Confalonieri, F. Tacconi, E. Mainardi, R. Della Porta, D. Ceccato, R. Maccario, M. De Amici

Research output: Contribution to journalArticle

Abstract

Background. Up to date, the etiology and the pathogenesis of HES are still unknown and particularly it is unclear why eosinophils in HES are more aggressive towards tissues than in other eosinophilic conditions. Methods. We assessed the cationic proteins ECP and EPX serum concentrations, their in vitro release from polymorphonuclear cell culture, and the monoclonal antibodies EG1 and EG2 in 3 patients with HES, 6 patients with other hypereosinophilic conditions and 20 healthy control subjects. Results. Serum ECP and EPX concentrations were higher in eosinophilic patients than in healthy subjects. Hypereosinophilic patients had more EG2+ cells than healthy subjects, but EG2+ rate failed to differentiate HES from other hypereosinophilic conditions (p=0.074). Moreover, the release in vitro of ECP and EPX was significantly higher in HES patients (p

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalPanminerva Medica
Volume40
Issue number3
Publication statusPublished - Sep 1998

Keywords

  • Blood proteins
  • Cations
  • Eosinophilia
  • Eosinophils
  • Hypereosinophilic syndrome

ASJC Scopus subject areas

  • Medicine(all)

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    Bobbio-Pallavicini, E., Confalonieri, M., Tacconi, F., Mainardi, E., Della Porta, R., Ceccato, D., Maccario, R., & De Amici, M. (1998). Study of release of eosinophil cationic proteins (ECP and EPX) in the hypereosinophilic syndrome (HES) and other hypereosinophilic conditions. Panminerva Medica, 40(3), 186-190.