Studio del ruolo combinato dell'amianto e di SV40 nella patogenesi del mesotelioma maligno

Translated title of the contribution: Study of the combined role of asbestos and SV40 in the pathogenesis of malignant mesothelioma

A. Cristaudo, R. Foddis, A. Vivaldi, R. Buselli, V. Gattini, G. Guglielmi, F. Cosentino, F. Ottenga, E. Ciancia, R. Libener, R. Filiberti, M. Neri, P. G. Betta, M. Tognon, L. Mutti, R. Puntoni

Research output: Contribution to journalArticle

Abstract

The preliminary results of a case-control study on asbestos exposure and SV40 in 11 malignant mesotheliomas (MMs) and 18 bladder urotheliomas (BUs) are reported, SV40 DNA was found in 7 (63.6%) MMs and in 6 (33.3%) BUs. A history of asbestos exposure was established in the cases of 8 MM patients (72.7%) and 4 BU patients (22.2%), In our small scale study, SV40 was positively associated with MMs from asbestos-exposed patients (OR 9.0, CL 0.5-143.8), but not with MMs from patients without asbestos exposure (OR 0.9, CL 0.06-12.5). The association between asbestos and MM in the whole population under study was clearly positive (OR 9.3, CL 1.6-52.7) and the strength of the association was higher when evaluated for SV40-positive MMs (30.0, CL 1.4-611.8). Our study suggests that SV40 plays a role as a co-factor with asbestos in MM pathogenesis.

Original languageItalian
Pages (from-to)48-50
Number of pages3
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume26
Issue number4 SUPPL.
Publication statusPublished - 2004

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Asbestos
Urinary Bladder
Malignant Mesothelioma
Case-Control Studies
DNA
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

Cite this

Cristaudo, A., Foddis, R., Vivaldi, A., Buselli, R., Gattini, V., Guglielmi, G., ... Puntoni, R. (2004). Studio del ruolo combinato dell'amianto e di SV40 nella patogenesi del mesotelioma maligno. Giornale Italiano di Medicina del Lavoro ed Ergonomia, 26(4 SUPPL.), 48-50.

Studio del ruolo combinato dell'amianto e di SV40 nella patogenesi del mesotelioma maligno. / Cristaudo, A.; Foddis, R.; Vivaldi, A.; Buselli, R.; Gattini, V.; Guglielmi, G.; Cosentino, F.; Ottenga, F.; Ciancia, E.; Libener, R.; Filiberti, R.; Neri, M.; Betta, P. G.; Tognon, M.; Mutti, L.; Puntoni, R.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 26, No. 4 SUPPL., 2004, p. 48-50.

Research output: Contribution to journalArticle

Cristaudo, A, Foddis, R, Vivaldi, A, Buselli, R, Gattini, V, Guglielmi, G, Cosentino, F, Ottenga, F, Ciancia, E, Libener, R, Filiberti, R, Neri, M, Betta, PG, Tognon, M, Mutti, L & Puntoni, R 2004, 'Studio del ruolo combinato dell'amianto e di SV40 nella patogenesi del mesotelioma maligno', Giornale Italiano di Medicina del Lavoro ed Ergonomia, vol. 26, no. 4 SUPPL., pp. 48-50.
Cristaudo A, Foddis R, Vivaldi A, Buselli R, Gattini V, Guglielmi G et al. Studio del ruolo combinato dell'amianto e di SV40 nella patogenesi del mesotelioma maligno. Giornale Italiano di Medicina del Lavoro ed Ergonomia. 2004;26(4 SUPPL.):48-50.
Cristaudo, A. ; Foddis, R. ; Vivaldi, A. ; Buselli, R. ; Gattini, V. ; Guglielmi, G. ; Cosentino, F. ; Ottenga, F. ; Ciancia, E. ; Libener, R. ; Filiberti, R. ; Neri, M. ; Betta, P. G. ; Tognon, M. ; Mutti, L. ; Puntoni, R. / Studio del ruolo combinato dell'amianto e di SV40 nella patogenesi del mesotelioma maligno. In: Giornale Italiano di Medicina del Lavoro ed Ergonomia. 2004 ; Vol. 26, No. 4 SUPPL. pp. 48-50.
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AU - Buselli, R.

AU - Gattini, V.

AU - Guglielmi, G.

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AU - Ciancia, E.

AU - Libener, R.

AU - Filiberti, R.

AU - Neri, M.

AU - Betta, P. G.

AU - Tognon, M.

AU - Mutti, L.

AU - Puntoni, R.

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