Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease

Louisa Goumidi, Frédéric Flamant, Corinne Lendon, Daniela Galimberti, Florence Pasquier, Elio Scarpini, Didier Hannequin, Dominique Campion, Philippe Amouyel, Jean Charles Lambert, Aline Meirhaeghe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Because the action of thyroid hormone (T3) is involved in adult cognitive functions, we wanted to assess the association between THRA gene polymorphisms, which encodes the T3 nuclear receptor TRα1, and Alzheimer's disease (AD) risk. We analysed 5 single nucleotide polymorphisms (SNPs) of THRA, covering the known common genetic variability of the gene, in the Lille AD case-control study (710 cases/597 controls). We observed that subjects bearing the rs939348 TT genotype had a tendency to have a higher risk of developing AD (adjusted OR [95%CI] = 1.71 [0.99-2.95] p= 0.06). We extended our finding to three other independent AD case-control studies and observed similar trends. When combining the 4 studies (1749 cases/1339 controls), we observed an overall significant higher risk of AD in TT subjects (adjusted OR [95%CI] = 1.42 [1.03-1.96], p= 0.03) compared with C allele bearers. However, when combining our data with the available data coming from 2 American genome wide association studies on AD, we observed a weak and not significant association (OR = 1.19 [0.97-1.45], p= 0.10). The relationship between the genetic variability of the THRA gene and AD risk remains uncertain but cannot be entirely excluded.

Original languageEnglish
Pages (from-to)624-630
Number of pages7
JournalNeurobiology of Aging
Volume32
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Thyroid Hormone Receptors alpha
Alzheimer Disease
erbA Genes
Genes
Case-Control Studies
Thyroid Hormone Receptors
Genome-Wide Association Study
Triiodothyronine
Cytoplasmic and Nuclear Receptors
Cognition
Single Nucleotide Polymorphism
Alleles
Genotype

Keywords

  • Alzheimer disease
  • Association studies
  • Genetic
  • Polymorphisms
  • THRA
  • Thyroid hormone
  • Thyroid hormone receptor alpha

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease. / Goumidi, Louisa; Flamant, Frédéric; Lendon, Corinne; Galimberti, Daniela; Pasquier, Florence; Scarpini, Elio; Hannequin, Didier; Campion, Dominique; Amouyel, Philippe; Lambert, Jean Charles; Meirhaeghe, Aline.

In: Neurobiology of Aging, Vol. 32, No. 4, 04.2011, p. 624-630.

Research output: Contribution to journalArticle

Goumidi, L, Flamant, F, Lendon, C, Galimberti, D, Pasquier, F, Scarpini, E, Hannequin, D, Campion, D, Amouyel, P, Lambert, JC & Meirhaeghe, A 2011, 'Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease', Neurobiology of Aging, vol. 32, no. 4, pp. 624-630. https://doi.org/10.1016/j.neurobiolaging.2009.04.007
Goumidi, Louisa ; Flamant, Frédéric ; Lendon, Corinne ; Galimberti, Daniela ; Pasquier, Florence ; Scarpini, Elio ; Hannequin, Didier ; Campion, Dominique ; Amouyel, Philippe ; Lambert, Jean Charles ; Meirhaeghe, Aline. / Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 4. pp. 624-630.
@article{634d389ca59f441bb66740ea055cec38,
title = "Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease",
abstract = "Because the action of thyroid hormone (T3) is involved in adult cognitive functions, we wanted to assess the association between THRA gene polymorphisms, which encodes the T3 nuclear receptor TRα1, and Alzheimer's disease (AD) risk. We analysed 5 single nucleotide polymorphisms (SNPs) of THRA, covering the known common genetic variability of the gene, in the Lille AD case-control study (710 cases/597 controls). We observed that subjects bearing the rs939348 TT genotype had a tendency to have a higher risk of developing AD (adjusted OR [95{\%}CI] = 1.71 [0.99-2.95] p= 0.06). We extended our finding to three other independent AD case-control studies and observed similar trends. When combining the 4 studies (1749 cases/1339 controls), we observed an overall significant higher risk of AD in TT subjects (adjusted OR [95{\%}CI] = 1.42 [1.03-1.96], p= 0.03) compared with C allele bearers. However, when combining our data with the available data coming from 2 American genome wide association studies on AD, we observed a weak and not significant association (OR = 1.19 [0.97-1.45], p= 0.10). The relationship between the genetic variability of the THRA gene and AD risk remains uncertain but cannot be entirely excluded.",
keywords = "Alzheimer disease, Association studies, Genetic, Polymorphisms, THRA, Thyroid hormone, Thyroid hormone receptor alpha",
author = "Louisa Goumidi and Fr{\'e}d{\'e}ric Flamant and Corinne Lendon and Daniela Galimberti and Florence Pasquier and Elio Scarpini and Didier Hannequin and Dominique Campion and Philippe Amouyel and Lambert, {Jean Charles} and Aline Meirhaeghe",
year = "2011",
month = "4",
doi = "10.1016/j.neurobiolaging.2009.04.007",
language = "English",
volume = "32",
pages = "624--630",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease

AU - Goumidi, Louisa

AU - Flamant, Frédéric

AU - Lendon, Corinne

AU - Galimberti, Daniela

AU - Pasquier, Florence

AU - Scarpini, Elio

AU - Hannequin, Didier

AU - Campion, Dominique

AU - Amouyel, Philippe

AU - Lambert, Jean Charles

AU - Meirhaeghe, Aline

PY - 2011/4

Y1 - 2011/4

N2 - Because the action of thyroid hormone (T3) is involved in adult cognitive functions, we wanted to assess the association between THRA gene polymorphisms, which encodes the T3 nuclear receptor TRα1, and Alzheimer's disease (AD) risk. We analysed 5 single nucleotide polymorphisms (SNPs) of THRA, covering the known common genetic variability of the gene, in the Lille AD case-control study (710 cases/597 controls). We observed that subjects bearing the rs939348 TT genotype had a tendency to have a higher risk of developing AD (adjusted OR [95%CI] = 1.71 [0.99-2.95] p= 0.06). We extended our finding to three other independent AD case-control studies and observed similar trends. When combining the 4 studies (1749 cases/1339 controls), we observed an overall significant higher risk of AD in TT subjects (adjusted OR [95%CI] = 1.42 [1.03-1.96], p= 0.03) compared with C allele bearers. However, when combining our data with the available data coming from 2 American genome wide association studies on AD, we observed a weak and not significant association (OR = 1.19 [0.97-1.45], p= 0.10). The relationship between the genetic variability of the THRA gene and AD risk remains uncertain but cannot be entirely excluded.

AB - Because the action of thyroid hormone (T3) is involved in adult cognitive functions, we wanted to assess the association between THRA gene polymorphisms, which encodes the T3 nuclear receptor TRα1, and Alzheimer's disease (AD) risk. We analysed 5 single nucleotide polymorphisms (SNPs) of THRA, covering the known common genetic variability of the gene, in the Lille AD case-control study (710 cases/597 controls). We observed that subjects bearing the rs939348 TT genotype had a tendency to have a higher risk of developing AD (adjusted OR [95%CI] = 1.71 [0.99-2.95] p= 0.06). We extended our finding to three other independent AD case-control studies and observed similar trends. When combining the 4 studies (1749 cases/1339 controls), we observed an overall significant higher risk of AD in TT subjects (adjusted OR [95%CI] = 1.42 [1.03-1.96], p= 0.03) compared with C allele bearers. However, when combining our data with the available data coming from 2 American genome wide association studies on AD, we observed a weak and not significant association (OR = 1.19 [0.97-1.45], p= 0.10). The relationship between the genetic variability of the THRA gene and AD risk remains uncertain but cannot be entirely excluded.

KW - Alzheimer disease

KW - Association studies

KW - Genetic

KW - Polymorphisms

KW - THRA

KW - Thyroid hormone

KW - Thyroid hormone receptor alpha

UR - http://www.scopus.com/inward/record.url?scp=79953030915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953030915&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2009.04.007

DO - 10.1016/j.neurobiolaging.2009.04.007

M3 - Article

C2 - 19427062

AN - SCOPUS:79953030915

VL - 32

SP - 624

EP - 630

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 4

ER -