Study on growth hormone and prolactin secretions in myotonic dystrophy

N. Canal, S. Smirne, G. Comi, F. Guidobono, A. Pecile, F. Caviezel

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Abstract

Basal and stimulated GH and PRL secretions were studied in 4 patients with myotonic dystrophy. High values of basal plasma GH were occasionally found in 2 patients. Abnormal plasma GH responses coexisted with normal ones after each stimulus (oral l-dopa, oral glucose load, arginine infusion, i.v. insulin, i.v. metoclopramide). Basal plasma PRL levels were normal in all patients as well as responses to different stimuli except the response to insulin-induced hypoglycemia that was abnormal in 3 patients out of 4. It is concluded that in myotonic dystrophy hypothalamic regulatory mechanisms of pituitary functions may be altered because of known thalamic lesions or, as yet, unrecognized hypothalamic ones.

Original languageEnglish
Pages (from-to)178-184
Number of pages7
JournalActa Neurologica Belgica
Volume82
Issue number3
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Canal, N., Smirne, S., Comi, G., Guidobono, F., Pecile, A., & Caviezel, F. (1982). Study on growth hormone and prolactin secretions in myotonic dystrophy. Acta Neurologica Belgica, 82(3), 178-184.