Styrene hepatotoxicity in rats treated by inhalation or intraperitoneally: A structural investigation

Paola De Piceis Polver, C. Fenoglio, R. Nano, T. Coccini, V. Bertone, R. Vaccarone, G. Gerzeli

Research output: Contribution to journalArticle


The purpose of this study was to investigate the toxicity of styrene in the liver of adult rats treated either by inhalation of styrene vapour (300 ppm, 6 h/d, 5 d/wk, for 2 wk) or intraperitoneally with different styrene doses (4, 40, 400 mg/Kg) for 3 consecutive days. Using a light microscope, some alterations of liver parenchyma and sinusoid dilation were noticed, more marked in the group treated with the intraperitoneal administration of the chemical. Using an electron microscope, some additional changes were observed (once again, more marked in the latter group of rats): a) an increase in the content of lipids inside hepatocytes, and b) the rise of intracytoplasmic, intercellular and perisinusoidal collagen fibres. Therefore, cell damage and functional disturbance of sinusoids due to perisinusoidal fibrosis are apparent in the liver of both groups of rats exposed to styrene treatment, but these changes are definitely more significant in those subjected to intraperitoneal administration.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalHistology and Histopathology
Issue number1
Publication statusPublished - Jan 2003



  • Liver
  • Rat
  • Structural alterations
  • Styrene

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Histology
  • Pathology and Forensic Medicine

Cite this

De Piceis Polver, P., Fenoglio, C., Nano, R., Coccini, T., Bertone, V., Vaccarone, R., & Gerzeli, G. (2003). Styrene hepatotoxicity in rats treated by inhalation or intraperitoneally: A structural investigation. Histology and Histopathology, 18(1), 49-54.