SU-8 based microprobes with integrated planar electrodes for enhanced neural depth recording

Ane Altuna, Liset Menendez de la Prida, Elisa Bellistri, Gemma Gabriel, Anton Guimerá, Javier Berganzo, Rosa Villa, Luis J. Fernández

Research output: Contribution to journalArticle

Abstract

Here, we describe new fabrication methods aimed to integrate planar tetrode-like electrodes into a polymer SU-8 based microprobe for neuronal recording applications. New concepts on the fabrication sequences are introduced in order to eliminate the typical electrode-tissue gap associated to the passivation layer. Optimization of the photolithography technique and high step coverage of the sputtering process have been critical steps in this new fabrication process. Impedance characterization confirmed the viability of the electrodes for reliable neuronal recordings with values comparable to commercial probes. Furthermore, a homogeneous sensing behavior was obtained in all the electrodes of each probe. Finally, . in vivo action potential and local field potential recordings were successfully obtained from the rat dorsal hippocampus. Peak-to-peak amplitude of action potentials ranged from noise level to up to 400-500. μV. Moreover, action potentials of different amplitudes and shapes were recorded from all the four recording sites, suggesting improved capability of the tetrode to distinguish from different neuronal sources.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalBiosensors and Bioelectronics
Volume37
Issue number1
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Action potential
  • Neural recording
  • SU-8 microprobe
  • Tetrode

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Biotechnology
  • Electrochemistry

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  • Cite this

    Altuna, A., Menendez de la Prida, L., Bellistri, E., Gabriel, G., Guimerá, A., Berganzo, J., Villa, R., & Fernández, L. J. (2012). SU-8 based microprobes with integrated planar electrodes for enhanced neural depth recording. Biosensors and Bioelectronics, 37(1), 1-5. https://doi.org/10.1016/j.bios.2012.03.039