Sub-inhibitory concentrations of brodimoprim inhibit adhesion of E. coli to human uroepithelial cells

P. C. Braga, G. Piatti, S. Reggio

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial adhesion to mucosal surfaces is a prerequisite for infection. Several antibiotics at sub-inhibitory concentrations (sub-MICs) have been shown to affect the adhesive ability of bacteria, usually decreasing adherence in vitro. The aim of the present study was to investigate the effect of brodimoprim, a broad-spectrum antibiotic, on E. coli adhesiveness to uroepithelial cells. Sub-inhibitory concentrations of brodimoprim, up to 1/16 MIC, significantly reduced the percentage of adhesion of E. coli to epithelial cells. At these concentrations, brodimoprim strongly diminished the adhesiveness of E. coli, causing the growth of filamentous shapes lacking in pili and therefore unable to adhere to epithelial cells.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume18
Issue number6
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

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