Sub-macular surgery: Is still an option for age-related macular degeneration?

Mario R. Romano, Xavier Valldeperas, Paolo Vinciguerra, David Wong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). Methods: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. Results: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD. At a 1-year follow-up, no benefit in preventing visual loss had been shown. Furthermore, complications occurred in the surgery arm such as retinal detachment and lens opacification. No differences have been found between submacular surgery and laser photocoagulation in terms of visual acuity and quality of life. As yet, there are no randomized controlled trials concerning retinal pigment epithelium and choroid translocation or macular translocation, but only prospective, non-controlled case series with low quality of evidence. Conclusions: No evidence of potential benefit from submacular removal of the CNV complex due to AMD has been shown. Randomized clinical trails (RCT) concerning other submacular surgical approaches are not available. There are sufficient non-comparative data on retinal pigment epithelium (RPE) graft to warrant an RCT especially in patients with large subretinal haemorrhages, RPE rip or in Anti-VEGF non-responders.

Original languageEnglish
Pages (from-to)190-198
Number of pages9
JournalCurrent Drug Targets
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Macular Degeneration
Surgery
Retinal Pigments
Retinal Pigment Epithelium
Choroid
Light Coagulation
Laser Therapy
Therapeutic Uses
Retinal Detachment
Grafts
MEDLINE
Vascular Endothelial Growth Factor A
Lenses
Visual Acuity
Multicenter Studies
Arm
Blood
Randomized Controlled Trials
Quality of Life
Observation

Keywords

  • Age-related macular degeneration
  • Choroidal transplant
  • Retinal pigment epithelium
  • Submacular surgery

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Sub-macular surgery : Is still an option for age-related macular degeneration? / Romano, Mario R.; Valldeperas, Xavier; Vinciguerra, Paolo; Wong, David.

In: Current Drug Targets, Vol. 12, No. 2, 02.2011, p. 190-198.

Research output: Contribution to journalArticle

Romano, Mario R. ; Valldeperas, Xavier ; Vinciguerra, Paolo ; Wong, David. / Sub-macular surgery : Is still an option for age-related macular degeneration?. In: Current Drug Targets. 2011 ; Vol. 12, No. 2. pp. 190-198.
@article{38b4730949f64af9a5a19a0e0e88401e,
title = "Sub-macular surgery: Is still an option for age-related macular degeneration?",
abstract = "Purpose: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). Methods: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. Results: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD. At a 1-year follow-up, no benefit in preventing visual loss had been shown. Furthermore, complications occurred in the surgery arm such as retinal detachment and lens opacification. No differences have been found between submacular surgery and laser photocoagulation in terms of visual acuity and quality of life. As yet, there are no randomized controlled trials concerning retinal pigment epithelium and choroid translocation or macular translocation, but only prospective, non-controlled case series with low quality of evidence. Conclusions: No evidence of potential benefit from submacular removal of the CNV complex due to AMD has been shown. Randomized clinical trails (RCT) concerning other submacular surgical approaches are not available. There are sufficient non-comparative data on retinal pigment epithelium (RPE) graft to warrant an RCT especially in patients with large subretinal haemorrhages, RPE rip or in Anti-VEGF non-responders.",
keywords = "Age-related macular degeneration, Choroidal transplant, Retinal pigment epithelium, Submacular surgery",
author = "Romano, {Mario R.} and Xavier Valldeperas and Paolo Vinciguerra and David Wong",
year = "2011",
month = "2",
doi = "10.2174/138945011794182700",
language = "English",
volume = "12",
pages = "190--198",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Sub-macular surgery

T2 - Is still an option for age-related macular degeneration?

AU - Romano, Mario R.

AU - Valldeperas, Xavier

AU - Vinciguerra, Paolo

AU - Wong, David

PY - 2011/2

Y1 - 2011/2

N2 - Purpose: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). Methods: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. Results: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD. At a 1-year follow-up, no benefit in preventing visual loss had been shown. Furthermore, complications occurred in the surgery arm such as retinal detachment and lens opacification. No differences have been found between submacular surgery and laser photocoagulation in terms of visual acuity and quality of life. As yet, there are no randomized controlled trials concerning retinal pigment epithelium and choroid translocation or macular translocation, but only prospective, non-controlled case series with low quality of evidence. Conclusions: No evidence of potential benefit from submacular removal of the CNV complex due to AMD has been shown. Randomized clinical trails (RCT) concerning other submacular surgical approaches are not available. There are sufficient non-comparative data on retinal pigment epithelium (RPE) graft to warrant an RCT especially in patients with large subretinal haemorrhages, RPE rip or in Anti-VEGF non-responders.

AB - Purpose: This review summarizes the data reported in peer-reviewed literature on the effects of submacular surgery for age-related macular degeneration (AMD) associated with choriodal neovascularization (CNV). Methods: A review of the MEDLINE database has been performed in order to examine the therapeutic effects of submacular surgical treatments in patients affected by AMD. Results: The multicenter studies conducted by the Submacular Surgery Trials Research Group compare the removal of the CNV complex, both with (336) and without blood (454), with observation in patients affected by AMD. At a 1-year follow-up, no benefit in preventing visual loss had been shown. Furthermore, complications occurred in the surgery arm such as retinal detachment and lens opacification. No differences have been found between submacular surgery and laser photocoagulation in terms of visual acuity and quality of life. As yet, there are no randomized controlled trials concerning retinal pigment epithelium and choroid translocation or macular translocation, but only prospective, non-controlled case series with low quality of evidence. Conclusions: No evidence of potential benefit from submacular removal of the CNV complex due to AMD has been shown. Randomized clinical trails (RCT) concerning other submacular surgical approaches are not available. There are sufficient non-comparative data on retinal pigment epithelium (RPE) graft to warrant an RCT especially in patients with large subretinal haemorrhages, RPE rip or in Anti-VEGF non-responders.

KW - Age-related macular degeneration

KW - Choroidal transplant

KW - Retinal pigment epithelium

KW - Submacular surgery

UR - http://www.scopus.com/inward/record.url?scp=79955644519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955644519&partnerID=8YFLogxK

U2 - 10.2174/138945011794182700

DO - 10.2174/138945011794182700

M3 - Article

C2 - 20887243

AN - SCOPUS:79955644519

VL - 12

SP - 190

EP - 198

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

IS - 2

ER -