Abstract
Neuropsychiatric manifestations are commonly observed in systemic lupus erythematosus (SLE) patients. In particular, neurological involvement is known to be more common in patients with positive anticardiolipin antibodies and lupus anticoagulants. Nevertheless, cerebellar ataxia has rarely been reported, especially as the first clinical manifestation of this systemic autoimmune disorder. Cerebral vascular infarction or ischemia, vasogenic oedema and antibody-mediated cerebral vasculopathy or vasculitic process have been supposed as possible aetiologies of acute cerebellar ataxia related to SLE. We report the clinical and radiological features of a woman who developed a rapidly progressive cerebellar syndrome as first sign of SLE; no other cause explaining her cerebellar ataxia was found. The patient improved after high-dose steroids. The appearance of a cerebellar syndrome with unknown aetiology with associated features of possible systemic autoimmune dysfunction, should be taken into account in clinical practice for appropriate diagnostic workup in order to provide effective therapeutic options.
| Original language | English |
|---|---|
| Pages (from-to) | 7401-7403 |
| Number of pages | 3 |
| Journal | European Review for Medical and Pharmacological Sciences |
| Volume | 22 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - Nov 1 2018 |
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Keywords
- Cerebellar ataxia
- LES
- Neurolupus
ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Subacute cerebellar ataxia as presenting symptom of systemic lupus erythematosus. / Casciato, S.; Mascia, A.; Quarato, P. P.; D'Aniello, A.; Scoppetta, C.; Di Gennaro, G.
In: European Review for Medical and Pharmacological Sciences, Vol. 22, No. 21, 01.11.2018, p. 7401-7403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subacute cerebellar ataxia as presenting symptom of systemic lupus erythematosus
AU - Casciato, S.
AU - Mascia, A.
AU - Quarato, P. P.
AU - D'Aniello, A.
AU - Scoppetta, C.
AU - Di Gennaro, G.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Neuropsychiatric manifestations are commonly observed in systemic lupus erythematosus (SLE) patients. In particular, neurological involvement is known to be more common in patients with positive anticardiolipin antibodies and lupus anticoagulants. Nevertheless, cerebellar ataxia has rarely been reported, especially as the first clinical manifestation of this systemic autoimmune disorder. Cerebral vascular infarction or ischemia, vasogenic oedema and antibody-mediated cerebral vasculopathy or vasculitic process have been supposed as possible aetiologies of acute cerebellar ataxia related to SLE. We report the clinical and radiological features of a woman who developed a rapidly progressive cerebellar syndrome as first sign of SLE; no other cause explaining her cerebellar ataxia was found. The patient improved after high-dose steroids. The appearance of a cerebellar syndrome with unknown aetiology with associated features of possible systemic autoimmune dysfunction, should be taken into account in clinical practice for appropriate diagnostic workup in order to provide effective therapeutic options.
AB - Neuropsychiatric manifestations are commonly observed in systemic lupus erythematosus (SLE) patients. In particular, neurological involvement is known to be more common in patients with positive anticardiolipin antibodies and lupus anticoagulants. Nevertheless, cerebellar ataxia has rarely been reported, especially as the first clinical manifestation of this systemic autoimmune disorder. Cerebral vascular infarction or ischemia, vasogenic oedema and antibody-mediated cerebral vasculopathy or vasculitic process have been supposed as possible aetiologies of acute cerebellar ataxia related to SLE. We report the clinical and radiological features of a woman who developed a rapidly progressive cerebellar syndrome as first sign of SLE; no other cause explaining her cerebellar ataxia was found. The patient improved after high-dose steroids. The appearance of a cerebellar syndrome with unknown aetiology with associated features of possible systemic autoimmune dysfunction, should be taken into account in clinical practice for appropriate diagnostic workup in order to provide effective therapeutic options.
KW - Cerebellar ataxia
KW - LES
KW - Neurolupus
UR - http://www.scopus.com/inward/record.url?scp=85056742662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056742662&partnerID=8YFLogxK
U2 - 10.26355/eurrev-201811-16279
DO - 10.26355/eurrev-201811-16279
M3 - Article
C2 - 30468487
AN - SCOPUS:85056742662
VL - 22
SP - 7401
EP - 7403
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
SN - 1128-3602
IS - 21
ER -