Subacute demyelinating polyneuropathy in B-cell lymphoma with IgM antibodies against glycolipid GD1b

Girolama A. Marfia, C. Pachatz, C. Terracciano, G. Leone, S. Bernardini, G. Bernardi, R. Massa

Research output: Contribution to journalArticle

Abstract

Peripheral neuropathy associated with IgM monoclonal gammopathy of unknown significance is a common disorder, while the association of paraproteinaemic neuropathies with haematological malignancies is far less frequent. We report a 76-year-old patient with a subacute and rapidly progressive sensorimotor demyelinating polyneuropathy causing sensory ataxia, painful paraesthesias and marked motor and sensory deficit in four limbs. Monoclonal gammopathy of IgM type associated with a rectal low-grade B-cell non-Hodgkin lymphoma was detected. Research for anti-MAG and antiganglioside autoantibodies including anti-GM1 and anti-GQ1b evidenced a high titre of IgM antibodies against the disialosyl group of GD1b. This is the first report on a paraproteinaemic polyneuropathy with IgM autoantibodies against glycolipid GD1b associated with B-cell lymphoma. The IgM type of these autoantibodies suggests that they represent all or part of the paraprotein produced by lymphoma cells.

Original languageEnglish
Pages (from-to)355-357
Number of pages3
JournalNeurological Sciences
Volume26
Issue number5
DOIs
Publication statusPublished - Dec 2005

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Keywords

  • B-cell lymphoma
  • Gangliosides
  • GD1b
  • Monoclonal gammopathy
  • Paraproteinaemic neuropathies

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Marfia, G. A., Pachatz, C., Terracciano, C., Leone, G., Bernardini, S., Bernardi, G., & Massa, R. (2005). Subacute demyelinating polyneuropathy in B-cell lymphoma with IgM antibodies against glycolipid GD1b. Neurological Sciences, 26(5), 355-357. https://doi.org/10.1007/s10072-005-0500-z