Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer

Roberta Vitaliani, Marco Spinazzi, Anna Rosa Mistro, Renzo Manara, Bruno Tavolato, Domenico Marco Bonifati

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ovarian carcinoma is a common gynecological malignancy. Distant metastases usually involve the liver and lung while neurological complications are rare. We describe the case of a 63-year-old woman diagnosed from an ovarian carcinoma with peritoneal seed, which was treated surgically and with chemotherapy. After 4 years she was admitted to our Department for the development of subacute right deafness, vertigo and imbalance. MRI revealed the presence of leptomeningeal carcinomatosis and an expansive formation in the right pontocerebellar angle, suggesting involvement of the right VIII cranial nerve. Examination of the cerebrospinal fluid disclosed the presence of neoplastic cells. Subsequently the patient rapidly deteriorated and eventually died. Involvement of VIII cranial nerve as the presentation of leptomeningeal carcinomatosis in ovarian carcinoma is rare. In the literature at least two other cases presented with deafness, suggesting that leptomeningeal carcinomatosis should be considered in the differential diagnosis when deafness appears in a cancer patient.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalNeurological Sciences
Volume30
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Meningeal Carcinomatosis
Vertigo
Deafness
Vestibulocochlear Nerve
Ovarian Neoplasms
Neoplasm Metastasis
Carcinoma
Cerebrospinal Fluid
Neoplasms
Seeds
Differential Diagnosis
Drug Therapy
Lung
Liver

Keywords

  • Deafness
  • Eighth cranial nerve
  • Leptomeningeal metastasis
  • Ovarian cancer
  • Vertigo

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

Cite this

Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer. / Vitaliani, Roberta; Spinazzi, Marco; Mistro, Anna Rosa; Manara, Renzo; Tavolato, Bruno; Bonifati, Domenico Marco.

In: Neurological Sciences, Vol. 30, No. 1, 2009, p. 65-67.

Research output: Contribution to journalArticle

Vitaliani, Roberta ; Spinazzi, Marco ; Mistro, Anna Rosa ; Manara, Renzo ; Tavolato, Bruno ; Bonifati, Domenico Marco. / Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer. In: Neurological Sciences. 2009 ; Vol. 30, No. 1. pp. 65-67.
@article{400934a6e18240f4b5195cf05b92789a,
title = "Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer",
abstract = "Ovarian carcinoma is a common gynecological malignancy. Distant metastases usually involve the liver and lung while neurological complications are rare. We describe the case of a 63-year-old woman diagnosed from an ovarian carcinoma with peritoneal seed, which was treated surgically and with chemotherapy. After 4 years she was admitted to our Department for the development of subacute right deafness, vertigo and imbalance. MRI revealed the presence of leptomeningeal carcinomatosis and an expansive formation in the right pontocerebellar angle, suggesting involvement of the right VIII cranial nerve. Examination of the cerebrospinal fluid disclosed the presence of neoplastic cells. Subsequently the patient rapidly deteriorated and eventually died. Involvement of VIII cranial nerve as the presentation of leptomeningeal carcinomatosis in ovarian carcinoma is rare. In the literature at least two other cases presented with deafness, suggesting that leptomeningeal carcinomatosis should be considered in the differential diagnosis when deafness appears in a cancer patient.",
keywords = "Deafness, Eighth cranial nerve, Leptomeningeal metastasis, Ovarian cancer, Vertigo",
author = "Roberta Vitaliani and Marco Spinazzi and Mistro, {Anna Rosa} and Renzo Manara and Bruno Tavolato and Bonifati, {Domenico Marco}",
year = "2009",
doi = "10.1007/s10072-008-0006-6",
language = "English",
volume = "30",
pages = "65--67",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "1",

}

TY - JOUR

T1 - Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer

AU - Vitaliani, Roberta

AU - Spinazzi, Marco

AU - Mistro, Anna Rosa

AU - Manara, Renzo

AU - Tavolato, Bruno

AU - Bonifati, Domenico Marco

PY - 2009

Y1 - 2009

N2 - Ovarian carcinoma is a common gynecological malignancy. Distant metastases usually involve the liver and lung while neurological complications are rare. We describe the case of a 63-year-old woman diagnosed from an ovarian carcinoma with peritoneal seed, which was treated surgically and with chemotherapy. After 4 years she was admitted to our Department for the development of subacute right deafness, vertigo and imbalance. MRI revealed the presence of leptomeningeal carcinomatosis and an expansive formation in the right pontocerebellar angle, suggesting involvement of the right VIII cranial nerve. Examination of the cerebrospinal fluid disclosed the presence of neoplastic cells. Subsequently the patient rapidly deteriorated and eventually died. Involvement of VIII cranial nerve as the presentation of leptomeningeal carcinomatosis in ovarian carcinoma is rare. In the literature at least two other cases presented with deafness, suggesting that leptomeningeal carcinomatosis should be considered in the differential diagnosis when deafness appears in a cancer patient.

AB - Ovarian carcinoma is a common gynecological malignancy. Distant metastases usually involve the liver and lung while neurological complications are rare. We describe the case of a 63-year-old woman diagnosed from an ovarian carcinoma with peritoneal seed, which was treated surgically and with chemotherapy. After 4 years she was admitted to our Department for the development of subacute right deafness, vertigo and imbalance. MRI revealed the presence of leptomeningeal carcinomatosis and an expansive formation in the right pontocerebellar angle, suggesting involvement of the right VIII cranial nerve. Examination of the cerebrospinal fluid disclosed the presence of neoplastic cells. Subsequently the patient rapidly deteriorated and eventually died. Involvement of VIII cranial nerve as the presentation of leptomeningeal carcinomatosis in ovarian carcinoma is rare. In the literature at least two other cases presented with deafness, suggesting that leptomeningeal carcinomatosis should be considered in the differential diagnosis when deafness appears in a cancer patient.

KW - Deafness

KW - Eighth cranial nerve

KW - Leptomeningeal metastasis

KW - Ovarian cancer

KW - Vertigo

UR - http://www.scopus.com/inward/record.url?scp=60449107676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60449107676&partnerID=8YFLogxK

U2 - 10.1007/s10072-008-0006-6

DO - 10.1007/s10072-008-0006-6

M3 - Article

VL - 30

SP - 65

EP - 67

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 1

ER -