TY - JOUR
T1 - Subatmospheric pressure in the rabbit pleural lymphatic network
AU - Negrini, Daniela
AU - Del Fabbro, Massimo
PY - 1999/11/1
Y1 - 1999/11/1
N2 - 1.Hydraulic pressure in intercostal and diaphragmatic lymphatic vessels was measured through the micropuncture technique in 23 anaesthetised paralysed rabbits. Pleural lymphatic vessels with diameters ranging from 55 to 950 μm were observed under stereomicroscope view about 3-4 h after intrapleural injection of 20% fluorescent dextrans. 2. Lymphatic pressure oscillated from a minimum (P(min)) to a maximum (P(max)) value, reflecting oscillations in phase with cardiac activity (cardiogenic oscillations) and lymphatic myogenic activity. With intact pleural space, P(min) in submesothelial diaphragmatic lymphatic vessels of the lateral apposition zone was -9.1 ± 4.2 mmHg, more subatmospheric than the simultaneously recorded pleural liquid pressure amounting to -3.9 ± 1.2 mmHg. In extrapleural intercostal lymphatic vessels P(min) averaged -1.3 ± 2.7 mmHg. 3. Cardiogenic pressure oscillations (P(max) - P(min)), were observed in all recordings; their mean amplitude was about 5 mmHg and was not dependent upon frequency of cardiac contraction, nor lymphatic vessel diameter, nor the P(min) value. 4. Intrinsic contractions of lymphatic vessel walls caused spontaneous pressure waves of about 7 mmHg in amplitude at a rate of 8 cycles min-1. 5. These results demonstrated the ability of pleural lymphatic vessels to generate pressure oscillations driving fluid from the subatmospheric pleural space into the lymphatic network.
AB - 1.Hydraulic pressure in intercostal and diaphragmatic lymphatic vessels was measured through the micropuncture technique in 23 anaesthetised paralysed rabbits. Pleural lymphatic vessels with diameters ranging from 55 to 950 μm were observed under stereomicroscope view about 3-4 h after intrapleural injection of 20% fluorescent dextrans. 2. Lymphatic pressure oscillated from a minimum (P(min)) to a maximum (P(max)) value, reflecting oscillations in phase with cardiac activity (cardiogenic oscillations) and lymphatic myogenic activity. With intact pleural space, P(min) in submesothelial diaphragmatic lymphatic vessels of the lateral apposition zone was -9.1 ± 4.2 mmHg, more subatmospheric than the simultaneously recorded pleural liquid pressure amounting to -3.9 ± 1.2 mmHg. In extrapleural intercostal lymphatic vessels P(min) averaged -1.3 ± 2.7 mmHg. 3. Cardiogenic pressure oscillations (P(max) - P(min)), were observed in all recordings; their mean amplitude was about 5 mmHg and was not dependent upon frequency of cardiac contraction, nor lymphatic vessel diameter, nor the P(min) value. 4. Intrinsic contractions of lymphatic vessel walls caused spontaneous pressure waves of about 7 mmHg in amplitude at a rate of 8 cycles min-1. 5. These results demonstrated the ability of pleural lymphatic vessels to generate pressure oscillations driving fluid from the subatmospheric pleural space into the lymphatic network.
UR - http://www.scopus.com/inward/record.url?scp=0033230305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033230305&partnerID=8YFLogxK
U2 - 10.1111/j.1469-7793.1999.00761.x
DO - 10.1111/j.1469-7793.1999.00761.x
M3 - Article
C2 - 10545142
AN - SCOPUS:0033230305
VL - 520
SP - 761
EP - 769
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 3
ER -