Subcellular distribution of the pi effect in the pancreas of the guinea pig

Pietro De Camilli, Jacopo Meldolesi

Research output: Contribution to journalArticlepeer-review


Pancreas lobules incubated in vitro actively incorporate (2-3H) myotnositol into the PI associated with a number of different membranes, i.e., those of the rough- and smooth-surfaced microsomes, mitochondria, zymogen granules, as well as the plasmalemma. Stimulation of secretion with Acetylcholine + Eserine results in an increase of the incorporation (PI effect). This increase is approximately of the same order of magnitude (∼ 4fold) in all the Fractions. The results might be due either to a generalized breakdown of the PI associated with all the membranes under study, Followed by resynthesis, or to a rapid intracellular redistribution of the PI molecules, synthetized in response to the stimulation.

Original languageEnglish
Pages (from-to)711-721
Number of pages11
JournalLife Sciences
Issue number4
Publication statusPublished - Aug 15 1974

ASJC Scopus subject areas

  • Pharmacology


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