TY - JOUR
T1 - Subcellular distribution of the pi effect in the pancreas of the guinea pig
AU - Camilli, Pietro De
AU - Meldolesi, Jacopo
PY - 1974/8/15
Y1 - 1974/8/15
N2 - Pancreas lobules incubated in vitro actively incorporate (2-3H) myotnositol into the PI associated with a number of different membranes, i.e., those of the rough- and smooth-surfaced microsomes, mitochondria, zymogen granules, as well as the plasmalemma. Stimulation of secretion with Acetylcholine + Eserine results in an increase of the incorporation (PI effect). This increase is approximately of the same order of magnitude (∼ 4fold) in all the Fractions. The results might be due either to a generalized breakdown of the PI associated with all the membranes under study, Followed by resynthesis, or to a rapid intracellular redistribution of the PI molecules, synthetized in response to the stimulation.
AB - Pancreas lobules incubated in vitro actively incorporate (2-3H) myotnositol into the PI associated with a number of different membranes, i.e., those of the rough- and smooth-surfaced microsomes, mitochondria, zymogen granules, as well as the plasmalemma. Stimulation of secretion with Acetylcholine + Eserine results in an increase of the incorporation (PI effect). This increase is approximately of the same order of magnitude (∼ 4fold) in all the Fractions. The results might be due either to a generalized breakdown of the PI associated with all the membranes under study, Followed by resynthesis, or to a rapid intracellular redistribution of the PI molecules, synthetized in response to the stimulation.
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U2 - 10.1016/0024-3205(74)90509-8
DO - 10.1016/0024-3205(74)90509-8
M3 - Article
C2 - 4549938
AN - SCOPUS:0016172543
VL - 15
SP - 711
EP - 721
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 4
ER -