Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population

Andrea Baragetti, G. Pisano, Cristina Bertelli, Katia Garlaschelli, Liliana Grigore, Anna Ludovica Fracanzani, Silvia Fargion, Giuseppe Danilo Norata, Alberico Luigi Catapano

Research output: Contribution to journalArticle

Abstract

Background and aims: Abdominal obesity and hepatic steatosis are ectopic fat depots associated with Metabolic Syndrome (MetS). Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. Therefore we studied whether different ectopic fat markers, and EFT in particular, are associated with MetS and markers of subclinical cardiovascular disease. Methods and results: 868 subjects from the PLIC Study were included, EFT, aortic calcifications, carotid Intima-Media Thickness (c-IMT) and echocardiographic parameters were determined by ultrasound; extra-cardiac atherosclerotic lesions were defined in presence of plaques at both carotid and aortic levels. Hepatic steatosis degrees were defined according to a scoring system. Abdominal adiposity was determined using Dual X-ray Absorbimetry (DEXA). Independently from age, women showed higher EFT versus men (4.5 (0.20-9.00) mm vs 4.00 (0.10-8.00) mm, p = 0.013); EFT was thicker in post-menopausal women (independently from hormone-replacement therapy). EFT, liver steatosis and abdominal adiposity increased with MetS (p <0.001). EFT was the only ectopic fat marker associated with cardiac dysfunction (OR = 1.340 [1.088-1.651 95% C.I., p = 0.006); liver steatosis and EFT were associated with extra-cardiac plaques (OR = 2.529 [1.328-4.819] 95% C.I., p <0.001 and OR = 1.195 [1.008-1.299] 95% C.I., p = 0.042; respectively). On top of cardiovascular risk factors, only EFT improved the discrimination of subjects with cardiac dysfunction and atherosclerotic plaques. Conclusions: EFT is associated with left ventricular dysfunction and subclinical atherosclerosis. Our data suggest that EFT may represent an additional tool for the stratification of cardiovascular risk.

Original languageEnglish
Pages (from-to)141-153
Number of pages13
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Atherosclerosis
Fats
Liver
Population
Adiposity
Fatty Liver
Carotid Intima-Media Thickness
Abdominal Obesity
Hormone Replacement Therapy
Left Ventricular Dysfunction
Atherosclerotic Plaques
Insulin Resistance
Cardiovascular Diseases
Obesity
X-Rays

Keywords

  • Cardiovascular
  • Epicardial fat
  • Steatosis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population. / Baragetti, Andrea; Pisano, G.; Bertelli, Cristina; Garlaschelli, Katia; Grigore, Liliana; Fracanzani, Anna Ludovica; Fargion, Silvia; Norata, Giuseppe Danilo; Catapano, Alberico Luigi.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 26, No. 2, 01.02.2016, p. 141-153.

Research output: Contribution to journalArticle

@article{a7f3297dda264a8ab33badea0cc20c30,
title = "Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population",
abstract = "Background and aims: Abdominal obesity and hepatic steatosis are ectopic fat depots associated with Metabolic Syndrome (MetS). Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. Therefore we studied whether different ectopic fat markers, and EFT in particular, are associated with MetS and markers of subclinical cardiovascular disease. Methods and results: 868 subjects from the PLIC Study were included, EFT, aortic calcifications, carotid Intima-Media Thickness (c-IMT) and echocardiographic parameters were determined by ultrasound; extra-cardiac atherosclerotic lesions were defined in presence of plaques at both carotid and aortic levels. Hepatic steatosis degrees were defined according to a scoring system. Abdominal adiposity was determined using Dual X-ray Absorbimetry (DEXA). Independently from age, women showed higher EFT versus men (4.5 (0.20-9.00) mm vs 4.00 (0.10-8.00) mm, p = 0.013); EFT was thicker in post-menopausal women (independently from hormone-replacement therapy). EFT, liver steatosis and abdominal adiposity increased with MetS (p <0.001). EFT was the only ectopic fat marker associated with cardiac dysfunction (OR = 1.340 [1.088-1.651 95{\%} C.I., p = 0.006); liver steatosis and EFT were associated with extra-cardiac plaques (OR = 2.529 [1.328-4.819] 95{\%} C.I., p <0.001 and OR = 1.195 [1.008-1.299] 95{\%} C.I., p = 0.042; respectively). On top of cardiovascular risk factors, only EFT improved the discrimination of subjects with cardiac dysfunction and atherosclerotic plaques. Conclusions: EFT is associated with left ventricular dysfunction and subclinical atherosclerosis. Our data suggest that EFT may represent an additional tool for the stratification of cardiovascular risk.",
keywords = "Cardiovascular, Epicardial fat, Steatosis",
author = "Andrea Baragetti and G. Pisano and Cristina Bertelli and Katia Garlaschelli and Liliana Grigore and Fracanzani, {Anna Ludovica} and Silvia Fargion and Norata, {Giuseppe Danilo} and Catapano, {Alberico Luigi}",
year = "2016",
month = "2",
day = "1",
doi = "10.1016/j.numecd.2015.10.013",
language = "English",
volume = "26",
pages = "141--153",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier B.V.",
number = "2",

}

TY - JOUR

T1 - Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population

AU - Baragetti, Andrea

AU - Pisano, G.

AU - Bertelli, Cristina

AU - Garlaschelli, Katia

AU - Grigore, Liliana

AU - Fracanzani, Anna Ludovica

AU - Fargion, Silvia

AU - Norata, Giuseppe Danilo

AU - Catapano, Alberico Luigi

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background and aims: Abdominal obesity and hepatic steatosis are ectopic fat depots associated with Metabolic Syndrome (MetS). Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. Therefore we studied whether different ectopic fat markers, and EFT in particular, are associated with MetS and markers of subclinical cardiovascular disease. Methods and results: 868 subjects from the PLIC Study were included, EFT, aortic calcifications, carotid Intima-Media Thickness (c-IMT) and echocardiographic parameters were determined by ultrasound; extra-cardiac atherosclerotic lesions were defined in presence of plaques at both carotid and aortic levels. Hepatic steatosis degrees were defined according to a scoring system. Abdominal adiposity was determined using Dual X-ray Absorbimetry (DEXA). Independently from age, women showed higher EFT versus men (4.5 (0.20-9.00) mm vs 4.00 (0.10-8.00) mm, p = 0.013); EFT was thicker in post-menopausal women (independently from hormone-replacement therapy). EFT, liver steatosis and abdominal adiposity increased with MetS (p <0.001). EFT was the only ectopic fat marker associated with cardiac dysfunction (OR = 1.340 [1.088-1.651 95% C.I., p = 0.006); liver steatosis and EFT were associated with extra-cardiac plaques (OR = 2.529 [1.328-4.819] 95% C.I., p <0.001 and OR = 1.195 [1.008-1.299] 95% C.I., p = 0.042; respectively). On top of cardiovascular risk factors, only EFT improved the discrimination of subjects with cardiac dysfunction and atherosclerotic plaques. Conclusions: EFT is associated with left ventricular dysfunction and subclinical atherosclerosis. Our data suggest that EFT may represent an additional tool for the stratification of cardiovascular risk.

AB - Background and aims: Abdominal obesity and hepatic steatosis are ectopic fat depots associated with Metabolic Syndrome (MetS). Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. Therefore we studied whether different ectopic fat markers, and EFT in particular, are associated with MetS and markers of subclinical cardiovascular disease. Methods and results: 868 subjects from the PLIC Study were included, EFT, aortic calcifications, carotid Intima-Media Thickness (c-IMT) and echocardiographic parameters were determined by ultrasound; extra-cardiac atherosclerotic lesions were defined in presence of plaques at both carotid and aortic levels. Hepatic steatosis degrees were defined according to a scoring system. Abdominal adiposity was determined using Dual X-ray Absorbimetry (DEXA). Independently from age, women showed higher EFT versus men (4.5 (0.20-9.00) mm vs 4.00 (0.10-8.00) mm, p = 0.013); EFT was thicker in post-menopausal women (independently from hormone-replacement therapy). EFT, liver steatosis and abdominal adiposity increased with MetS (p <0.001). EFT was the only ectopic fat marker associated with cardiac dysfunction (OR = 1.340 [1.088-1.651 95% C.I., p = 0.006); liver steatosis and EFT were associated with extra-cardiac plaques (OR = 2.529 [1.328-4.819] 95% C.I., p <0.001 and OR = 1.195 [1.008-1.299] 95% C.I., p = 0.042; respectively). On top of cardiovascular risk factors, only EFT improved the discrimination of subjects with cardiac dysfunction and atherosclerotic plaques. Conclusions: EFT is associated with left ventricular dysfunction and subclinical atherosclerosis. Our data suggest that EFT may represent an additional tool for the stratification of cardiovascular risk.

KW - Cardiovascular

KW - Epicardial fat

KW - Steatosis

UR - http://www.scopus.com/inward/record.url?scp=84959115843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959115843&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2015.10.013

DO - 10.1016/j.numecd.2015.10.013

M3 - Article

VL - 26

SP - 141

EP - 153

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 2

ER -