Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and aims Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease. Methods In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. hypertension, diabetes, hypercholesterolemia, obesity). Results The results suggest that subjects with histologically proven NAFLD have a reduced cerebral perfusion (CBFr) confined to limited brain areas, i.e., left semioval center and posterior cingulate cortex. No statistically significant differences in CBFr values were found, dividing the NAFLD cohort into subgroups, considering NAS score, presence/absence of NASH/fibrosis, and degree of steatosis. Conclusions Our data suggest that NAFLD per se may be involved in cerebral atherosclerotic disease. It will be interesting to draw longitudinal studies to determine whether these changes could evolve in more serious cerebral injury.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalAtherosclerosis
Volume268
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Cerebrovascular Disorders
Atherosclerosis
Perfusion
Gyrus Cinguli
Brain
Hypercholesterolemia
Blood Vessels
Longitudinal Studies
Fibrosis
Cardiovascular Diseases
Magnetic Resonance Spectroscopy
Obesity
Non-alcoholic Fatty Liver Disease
Hypertension
Wounds and Injuries

Keywords

  • Atherosclerosis
  • Cerebral blood flow
  • Cerebrovascular disease
  • Magnetic resonance spectroscopy (MRS)
  • Metabolic syndrome
  • Non-alcoholic fatty liver disease (NAFLD)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis. / Airaghi, Lorena; Rango, Mario; Maira, Diletta; Barbieri, Valentina; Valenti, Luca; Lombardi, Rosa; Biondetti, Pietro; Fargion, Silvia; Fracanzani, Anna Ludovica.

In: Atherosclerosis, Vol. 268, 01.01.2018, p. 27-31.

Research output: Contribution to journalArticle

@article{4704686d535f4180bc4244ee8ea3eeb1,
title = "Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis",
abstract = "Background and aims Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease. Methods In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. hypertension, diabetes, hypercholesterolemia, obesity). Results The results suggest that subjects with histologically proven NAFLD have a reduced cerebral perfusion (CBFr) confined to limited brain areas, i.e., left semioval center and posterior cingulate cortex. No statistically significant differences in CBFr values were found, dividing the NAFLD cohort into subgroups, considering NAS score, presence/absence of NASH/fibrosis, and degree of steatosis. Conclusions Our data suggest that NAFLD per se may be involved in cerebral atherosclerotic disease. It will be interesting to draw longitudinal studies to determine whether these changes could evolve in more serious cerebral injury.",
keywords = "Atherosclerosis, Cerebral blood flow, Cerebrovascular disease, Magnetic resonance spectroscopy (MRS), Metabolic syndrome, Non-alcoholic fatty liver disease (NAFLD)",
author = "Lorena Airaghi and Mario Rango and Diletta Maira and Valentina Barbieri and Luca Valenti and Rosa Lombardi and Pietro Biondetti and Silvia Fargion and Fracanzani, {Anna Ludovica}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.atherosclerosis.2017.11.012",
language = "English",
volume = "268",
pages = "27--31",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Subclinical cerebrovascular disease in NAFLD without overt risk factors for atherosclerosis

AU - Airaghi, Lorena

AU - Rango, Mario

AU - Maira, Diletta

AU - Barbieri, Valentina

AU - Valenti, Luca

AU - Lombardi, Rosa

AU - Biondetti, Pietro

AU - Fargion, Silvia

AU - Fracanzani, Anna Ludovica

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and aims Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease. Methods In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. hypertension, diabetes, hypercholesterolemia, obesity). Results The results suggest that subjects with histologically proven NAFLD have a reduced cerebral perfusion (CBFr) confined to limited brain areas, i.e., left semioval center and posterior cingulate cortex. No statistically significant differences in CBFr values were found, dividing the NAFLD cohort into subgroups, considering NAS score, presence/absence of NASH/fibrosis, and degree of steatosis. Conclusions Our data suggest that NAFLD per se may be involved in cerebral atherosclerotic disease. It will be interesting to draw longitudinal studies to determine whether these changes could evolve in more serious cerebral injury.

AB - Background and aims Non-alcoholic fatty liver disease is recognized not only as part of the metabolic syndrome but also as an independent predictor of cardiovascular disease. Methods In this study, NMR spectroscopy method, together with perfusion techniques, was used to detect subclinical brain vascular damage in subjects with NAFLD without overt atherosclerosis risk factors (i.e. hypertension, diabetes, hypercholesterolemia, obesity). Results The results suggest that subjects with histologically proven NAFLD have a reduced cerebral perfusion (CBFr) confined to limited brain areas, i.e., left semioval center and posterior cingulate cortex. No statistically significant differences in CBFr values were found, dividing the NAFLD cohort into subgroups, considering NAS score, presence/absence of NASH/fibrosis, and degree of steatosis. Conclusions Our data suggest that NAFLD per se may be involved in cerebral atherosclerotic disease. It will be interesting to draw longitudinal studies to determine whether these changes could evolve in more serious cerebral injury.

KW - Atherosclerosis

KW - Cerebral blood flow

KW - Cerebrovascular disease

KW - Magnetic resonance spectroscopy (MRS)

KW - Metabolic syndrome

KW - Non-alcoholic fatty liver disease (NAFLD)

UR - http://www.scopus.com/inward/record.url?scp=85034659546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034659546&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2017.11.012

DO - 10.1016/j.atherosclerosis.2017.11.012

M3 - Article

AN - SCOPUS:85034659546

VL - 268

SP - 27

EP - 31

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -