TY - JOUR
T1 - Subclinical hyperthyroidism and cardiovascular manifestations
T2 - A reevaluation of the association
AU - Carpi, Angelo
AU - Cini, Giuseppe
AU - Russo, Matteo
AU - Antonelli, Alessandro
AU - Gaudio, Carlo
AU - Galetta, Fabio
AU - Franzoni, Ferdinando
AU - Rossi, Giuseppe
PY - 2013
Y1 - 2013
N2 - Subclinical hyperthyroidism (SH) has been reported associated with atrial fibrillation (AF), heart failure (HF) and coronary heart disease events, including mortality. An expert opinion indicates that AF is the possible link between SH and the other important cardiovascular (CV) manifestations. We analyzed the data of three recent studies including 60,883 subjects of whom 2,284 SH patients. In these subjects, the ratio between the AF events and each of the other above reported CV events varied from 0. 14 to 0. 4 in SH and from 0. 2 to 2. 4 in euthyroidism (ET). The general pattern of this ratio in 6 comparisons performed was not significantly higher for SH than ET. This data suggest that AF is not the major link between SH and the related CV manifestations. We suggest that a further link to be considered is the higher frequency of the early atherosclerosis manifestations such as carotid intima media thickness or carotid integrated back scatter, observed in SH. This atherogenic effect of SH can affect the occurrence of all the above clinical CV manifestations.
AB - Subclinical hyperthyroidism (SH) has been reported associated with atrial fibrillation (AF), heart failure (HF) and coronary heart disease events, including mortality. An expert opinion indicates that AF is the possible link between SH and the other important cardiovascular (CV) manifestations. We analyzed the data of three recent studies including 60,883 subjects of whom 2,284 SH patients. In these subjects, the ratio between the AF events and each of the other above reported CV events varied from 0. 14 to 0. 4 in SH and from 0. 2 to 2. 4 in euthyroidism (ET). The general pattern of this ratio in 6 comparisons performed was not significantly higher for SH than ET. This data suggest that AF is not the major link between SH and the related CV manifestations. We suggest that a further link to be considered is the higher frequency of the early atherosclerosis manifestations such as carotid intima media thickness or carotid integrated back scatter, observed in SH. This atherogenic effect of SH can affect the occurrence of all the above clinical CV manifestations.
KW - Atrial fibrillation
KW - Cardiovascular disease
KW - Subclinical hyperthyroidism
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U2 - 10.1007/s11739-013-0913-2
DO - 10.1007/s11739-013-0913-2
M3 - Article
C2 - 23462890
AN - SCOPUS:84875653905
VL - 8
SP - 75
EP - 77
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - SUPPL. 1
ER -