Abstract
In a patient chronically treated with amiodarone, subclinical iodine-induced hypothyroidism occurred as a result of excess iodine released from the amiodarone molecule. The patient was maintained on amiodarone and developed thyrotoxicosis as a result of a destructive process into the thyroid follicles. Amiodarone was withdrawn and methylprednisolone and methimazole treatment was started with resolution of the thyrotoxic phase. Months later, off therapy, the patient developed subclinical hypothyroidism. This is the first description of hypo-and hyperthyroidism in the same patient caused by amiodarone therapy. This unusual observation suggests that patients treated with amiodarone are at risk to develop hyperthyroidism even if they show laboratory findings consistent with hypothyroidism.
| Original language | English |
|---|---|
| Pages (from-to) | 853-855 |
| Number of pages | 3 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 15 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Amiodarone
- hypothyroidism
- thyrotoxicosis
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Subclinical hypothyroidism, overt thyrotoxicosis and subclinical hypothyroidism : The subsequent phases of thyroid function in a patient chronically treated with amiodarone. / Minelli, R.; Gardini, E.; Bianconi, L.; Salvi, M.; Roti, Elio.
In: Journal of Endocrinological Investigation, Vol. 15, No. 11, 1992, p. 853-855.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subclinical hypothyroidism, overt thyrotoxicosis and subclinical hypothyroidism
T2 - The subsequent phases of thyroid function in a patient chronically treated with amiodarone
AU - Minelli, R.
AU - Gardini, E.
AU - Bianconi, L.
AU - Salvi, M.
AU - Roti, Elio
PY - 1992
Y1 - 1992
N2 - In a patient chronically treated with amiodarone, subclinical iodine-induced hypothyroidism occurred as a result of excess iodine released from the amiodarone molecule. The patient was maintained on amiodarone and developed thyrotoxicosis as a result of a destructive process into the thyroid follicles. Amiodarone was withdrawn and methylprednisolone and methimazole treatment was started with resolution of the thyrotoxic phase. Months later, off therapy, the patient developed subclinical hypothyroidism. This is the first description of hypo-and hyperthyroidism in the same patient caused by amiodarone therapy. This unusual observation suggests that patients treated with amiodarone are at risk to develop hyperthyroidism even if they show laboratory findings consistent with hypothyroidism.
AB - In a patient chronically treated with amiodarone, subclinical iodine-induced hypothyroidism occurred as a result of excess iodine released from the amiodarone molecule. The patient was maintained on amiodarone and developed thyrotoxicosis as a result of a destructive process into the thyroid follicles. Amiodarone was withdrawn and methylprednisolone and methimazole treatment was started with resolution of the thyrotoxic phase. Months later, off therapy, the patient developed subclinical hypothyroidism. This is the first description of hypo-and hyperthyroidism in the same patient caused by amiodarone therapy. This unusual observation suggests that patients treated with amiodarone are at risk to develop hyperthyroidism even if they show laboratory findings consistent with hypothyroidism.
KW - Amiodarone
KW - hypothyroidism
KW - thyrotoxicosis
UR - http://www.scopus.com/inward/record.url?scp=0027008727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027008727&partnerID=8YFLogxK
U2 - 10.1007/BF03348819
DO - 10.1007/BF03348819
M3 - Article
C2 - 1291598
AN - SCOPUS:0027008727
VL - 15
SP - 853
EP - 855
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 11
ER -