Abstract
Background: Visual perception deficits are a recurrent manifestation in Parkinson's disease (PD). Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations. The aim of the present study was to investigate the salient aspects of visual perception in cognitively unimpaired PD patients. Methods: Eleven right-handed non-demented right-sided onset PD patients without visuospatial impairment or hallucinations and 11 healthy controls were studied with functional magnetic resonance imaging while performing a specific visuoperceptual/visuospatial paradigm that allowed to highlight the specific process underlying visuospatial judgment. Results: Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed. In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere. Conclusions: We found that both loss of efficiency and compensatory mechanisms occur in PD patients, providing further insight into the pathophysiological role of the functional alterations of basal ganglia and limbic structures in the impairment of visuoperceptual and visuospatial functions observed in PD.
| Original language | English |
|---|---|
| Article number | Article 152 |
| Journal | Frontiers in Neurology |
| Volume | 5 AUG |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- fMRI
- Hippocampus
- Insula
- Parkinson's disease
- Visuospatial/cognitive impairment
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Subclinical visuospatial impairment in Parkinson's disease : The role of basal ganglia and limbic system. / Caproni, Stefano; Muti, Marco; Di Renzo, Antonio; Principi, Massimo; Caputo, Nevia; Calabresi, Paolo; Tambasco, Nicola.
In: Frontiers in Neurology, Vol. 5 AUG, Article 152, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subclinical visuospatial impairment in Parkinson's disease
T2 - The role of basal ganglia and limbic system
AU - Caproni, Stefano
AU - Muti, Marco
AU - Di Renzo, Antonio
AU - Principi, Massimo
AU - Caputo, Nevia
AU - Calabresi, Paolo
AU - Tambasco, Nicola
PY - 2014
Y1 - 2014
N2 - Background: Visual perception deficits are a recurrent manifestation in Parkinson's disease (PD). Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations. The aim of the present study was to investigate the salient aspects of visual perception in cognitively unimpaired PD patients. Methods: Eleven right-handed non-demented right-sided onset PD patients without visuospatial impairment or hallucinations and 11 healthy controls were studied with functional magnetic resonance imaging while performing a specific visuoperceptual/visuospatial paradigm that allowed to highlight the specific process underlying visuospatial judgment. Results: Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed. In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere. Conclusions: We found that both loss of efficiency and compensatory mechanisms occur in PD patients, providing further insight into the pathophysiological role of the functional alterations of basal ganglia and limbic structures in the impairment of visuoperceptual and visuospatial functions observed in PD.
AB - Background: Visual perception deficits are a recurrent manifestation in Parkinson's disease (PD). Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations. The aim of the present study was to investigate the salient aspects of visual perception in cognitively unimpaired PD patients. Methods: Eleven right-handed non-demented right-sided onset PD patients without visuospatial impairment or hallucinations and 11 healthy controls were studied with functional magnetic resonance imaging while performing a specific visuoperceptual/visuospatial paradigm that allowed to highlight the specific process underlying visuospatial judgment. Results: Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed. In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere. Conclusions: We found that both loss of efficiency and compensatory mechanisms occur in PD patients, providing further insight into the pathophysiological role of the functional alterations of basal ganglia and limbic structures in the impairment of visuoperceptual and visuospatial functions observed in PD.
KW - fMRI
KW - Hippocampus
KW - Insula
KW - Parkinson's disease
KW - Visuospatial/cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=84906499663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906499663&partnerID=8YFLogxK
U2 - 10.3389/fneur.2014.00152
DO - 10.3389/fneur.2014.00152
M3 - Article
AN - SCOPUS:84906499663
VL - 5 AUG
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
M1 - Article 152
ER -