Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis

N. Bergsland, D. Horakova, M. G. Dwyer, O. Dolezal, Z. K. Seidl, M. Vaneckova, J. Krasensky, E. Havrdova, Robert Zivadinov

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: Recent studies have shown that selective regional, but not global, GM atrophy occurs from clinical onset to conversion to clinically definite MS. Our aim was to investigate the difference in the extent of SDGM and cortical atrophy in a large sample of patients with CIS and early RRMS and to explore the relationship between SDGM and cortical atrophy and other MR imaging and clinical outcomes. MATERIALS AND METHODS: Two hundred twelve patients with CIS recruited at the first clinical event (mean age, 29.3 years; median EDSS, 1.5; median disease duration, 3 months) and 177 patients with early RRMS (mean age, 30.7 years; median EDSS, 2.0; median disease duration, 47 months) were imaged on a 1.5T scanner by using a high-resolution 3D T1 spoiled gradient-recalled sequence. Volumetric data for SDGM structures were obtained by using FSL FIRST, while whole-brain, GM, white matter, cortical, and lateral ventricle volumes were estimated by using SIENAX software. Comparisons between the groups were adjusted for age and sex. RESULTS: Patients with early RRMS showed significantly lower SDGM but not cortical volumes compared with patients with CIS. The most apparent SDGM differences were evident in the caudate and thalamus (P <.0001), total SDGM (P = .0001), and globus pallidus (P = .01). Patients with CIS with a median T2 lesion volume >4.49 mL showed lower total SDGM, caudate, thalamus (P <.001), globus pallidus (P = .007), hippocampus (P = .004), and putamen (P = .01) volumes and higher lateral ventricle volume (P = .001) than those with a median T2 lesion volume

Original languageEnglish
Pages (from-to)1573-1578
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume33
Issue number8
DOIs
Publication statusPublished - Sep 2012

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Relapsing-Remitting Multiple Sclerosis
Atrophy
Lateral Ventricles
Thalamus
Globus Pallidus
Putamen
Hippocampus
Software
Gray Matter
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis. / Bergsland, N.; Horakova, D.; Dwyer, M. G.; Dolezal, O.; Seidl, Z. K.; Vaneckova, M.; Krasensky, J.; Havrdova, E.; Zivadinov, Robert.

In: American Journal of Neuroradiology, Vol. 33, No. 8, 09.2012, p. 1573-1578.

Research output: Contribution to journalArticle

Bergsland, N. ; Horakova, D. ; Dwyer, M. G. ; Dolezal, O. ; Seidl, Z. K. ; Vaneckova, M. ; Krasensky, J. ; Havrdova, E. ; Zivadinov, Robert. / Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis. In: American Journal of Neuroradiology. 2012 ; Vol. 33, No. 8. pp. 1573-1578.
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T1 - Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis

AU - Bergsland, N.

AU - Horakova, D.

AU - Dwyer, M. G.

AU - Dolezal, O.

AU - Seidl, Z. K.

AU - Vaneckova, M.

AU - Krasensky, J.

AU - Havrdova, E.

AU - Zivadinov, Robert

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AB - BACKGROUND AND PURPOSE: Recent studies have shown that selective regional, but not global, GM atrophy occurs from clinical onset to conversion to clinically definite MS. Our aim was to investigate the difference in the extent of SDGM and cortical atrophy in a large sample of patients with CIS and early RRMS and to explore the relationship between SDGM and cortical atrophy and other MR imaging and clinical outcomes. MATERIALS AND METHODS: Two hundred twelve patients with CIS recruited at the first clinical event (mean age, 29.3 years; median EDSS, 1.5; median disease duration, 3 months) and 177 patients with early RRMS (mean age, 30.7 years; median EDSS, 2.0; median disease duration, 47 months) were imaged on a 1.5T scanner by using a high-resolution 3D T1 spoiled gradient-recalled sequence. Volumetric data for SDGM structures were obtained by using FSL FIRST, while whole-brain, GM, white matter, cortical, and lateral ventricle volumes were estimated by using SIENAX software. Comparisons between the groups were adjusted for age and sex. RESULTS: Patients with early RRMS showed significantly lower SDGM but not cortical volumes compared with patients with CIS. The most apparent SDGM differences were evident in the caudate and thalamus (P <.0001), total SDGM (P = .0001), and globus pallidus (P = .01). Patients with CIS with a median T2 lesion volume >4.49 mL showed lower total SDGM, caudate, thalamus (P <.001), globus pallidus (P = .007), hippocampus (P = .004), and putamen (P = .01) volumes and higher lateral ventricle volume (P = .001) than those with a median T2 lesion volume

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